Neurovirulence in mice of soluble receptor-resistant (srr) mutants of mouse hepatitis virus: Intensive apoptosis caused by less virulent srr mutant

Archives of Virology

Volumn 146, Issue 9, 2001, Pages 1643-1654

  Matsuyama, S ^a   Watanabe, R ^b   Taguchi, F ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b SOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN DETECTION; APOPTOSIS; CELL GROWTH; GENETIC STRAIN; HEPATITIS VIRUS; INOCULATION; MUTANT; PROTEIN S; TISSUE DISTRIBUTION; VIRUS ANTIGEN; VIRUS MUTATION; VIRUS VIRULENCE; WILD RELATIVE;

ANIMALS; APOPTOSIS; BRAIN; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM VIRAL DISEASES; CORONAVIRUS INFECTIONS; LIVER; MACROPHAGES, PERITONEAL; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED ICR; MURINE HEPATITIS VIRUS; MUTATION; RECEPTORS, VIRUS; SOLUBILITY; SPINAL CORD; VIRAL ENVELOPE PROTEINS;

EID: 0034809509     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050170053     Document Type: Article

References (38)

1. Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer
2. Involvement of interleukin-1beta in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp 120-induced apoptosis in the neocortex of rat
3. Apoptosis reduces both the invitro replication and the in vivo infection of a baculovirus
4. Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence
5. Evidence for a coiled-coil structure in the spike of coronaviruses
6. Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59
7. Cloning of the mouse hepatitis virus (MHV) receptor: Expression in human and hamster cell lines confers susceptibility to MHV
8. Neuronal death in cytokine-activated primary human brain cell culture: Role of tumor necrosis factor-alpha
9. Interleukin (IL)-1beta-mediated apoptosis of human astrocytes
10. Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies
11. Cytokine-mediated survival from lethal herpes simplex virus infection: Role of programmed neuronal death
12. Site-specific mutagenesis of the 35-kilodalton protein gene encoded by Autographa california nuclear polyhedrosis virus: Cell line-specific effects on virus replication
13. Apoptosis: A mechanism of cell killing by Influenza A and B viruses
14. Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture
15. Analysis of the function of coronavirus glycoprotein by differential inhibition of synthesis with tunicamycin
16. Apoptosis plays an important role in experimental rabies virus infection
17. Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: Crossing the host cell species barrier
18. Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence
19. Bcl-2 protects mice against fatal alphavirus encephalitis
20. Optimization of targeted RNA recombination and mapping of a novel nucleocapsid gene mutation in the coronavirus mouse hepatitis virus
21. Neurovirulence of six different murine coronavirus JHMV variants for rats
22. Impaired entry of soluble receptor-resistant mutants of mouse hepatitis virus into cells expressing MHVR2 receptor
23. Potential role of CD4C+ T cell-mediated apoptosis of activated astrocytes in Theiler's virus-induced demyelination
24. Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo
25. Pathogenesis of chimeric MHV4/MHV-A59 recombinant viruses: The murine coronavirus spike protein is a major determinant of neurovirulence
26. Identification of spike protein residues of murine coronavirus responsible for receptor-binding activity by use of soluble receptor-resistant mutants
27. Coronaviruses: Structure and genome expression
28. Proteolytic cleavage of the E2 glycoprotein of murine coronavirus: Activation of cell fusing activity of virions by trypsin and separation of two different 90 K cleavage fragments
29. Enhanced growth of a murine coronavirus in transformed mouse cells
30. Biological functions of mouse hepatitis virus (MHV) spike (S) protein and implication of S protein-MHV receptor interaction in virus virulence
31. Difference in response of mouse hepatitis virus among susceptible mouse strains
32. Characterization of a variant virus selected in rat brain after infection by coronavirus mouse hepatitis virus JHM
33. Resistance to highly virulent mouse hepatitis virus acquired by mice after low-virulence infection: Enhanced antiviral activity of macrophages
34. Sequence analysis of the spike protein gene of murine coronavirus variants: Study of genetic site affecting neuropathogenicity
35. The biology and pathogenesis of coronaviruses
36. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins
37. Macrophage infiltration, but not apoptosis, is correlated with immune-mediated demyelination following murine infection with a neurotropic coronavirus
38. The receptor for mouse hepatitis virus in the resistant mouse strain SJL is functional: Implication for the requirement of a second factor for virus infection