Effects of methylprednisolone and aprotinin on phospholipase D activity of leukocytes in systemic inflammatory response induced by cardiopulmonary bypass

Acta Pharmacologica Sinica

Volumn 22, Issue 10, 2001, Pages 913-917

  Wu, M ^a   Lu, Y B ^a   Jiang, B ^a   Xu, S W ^a   Chen, R K ^a   Zhou, H L ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Aprotinin; Cardiopulmonary bypass; Inflammation; Leukocytes; Methylprednisolone; Phospholipase D

Indexed keywords

APROTININ; C REACTIVE PROTEIN; CD11B ANTIGEN; CHOLINE; INTERLEUKIN 6; INTERLEUKIN 8; METHYLPREDNISOLONE; MYELOPEROXIDASE; PHOSPHOLIPASE D; ANTI INFLAMMATORY AGENTS, STEROIDAL; ANTIINFLAMMATORY AGENT;

ADOLESCENT; ADULT; AGED; AORTA CLAMPING; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CYTOKINE RELEASE; DESCENDING AORTA; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; LEUKOCYTE; MALE; OPEN HEART SURGERY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TREATMENT OUTCOME; BLOOD; CONGENITAL HEART MALFORMATION; ENZYMOLOGY; SEPSIS; VALVULAR HEART DISEASE;

ADOLESCENT; ADULT; AGED; ANTI-INFLAMMATORY AGENTS, STEROIDAL; APROTININ; CARDIOPULMONARY BYPASS; FEMALE; HEART DEFECTS, CONGENITAL; HEART VALVE DISEASES; HUMAN; LEUKOCYTES; MALE; METHYLPREDNISOLONE; MIDDLE AGE; PHOSPHOLIPASE D; SEPSIS SYNDROME; SUPPORT, NON-U.S. GOV'T;

EID: 0034809457     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Cardiopulmonary bypass renders patients at risk for multiple organ failure via early neutrophil priming and late neutrophil disability
2. Phospholipase D and membrane traffic potential role in regulated exocytosis, membrane delivery and vesicle
3. A novel polyisoprenyl phosphate signaling cascade in human neutrophils
4. Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils
5. Changes of phospholipase D activity of exudates leukocytes in rat carrageenaninduced pleurisy
6. Relationship between phospholipase D and inflammation
7. Phospholipase D: A novel major player in signal transduction
8. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
9. Effects of ketotifen on human neurophil respiratory burst and intracellular free calcium
10. Effects of salbutamol and sodium cromoglicate on phospholipase D activity during the degranulation of rat peritoneal mast cell
11. Reducing the post-pump syndrome by using heparin-coated circuits, steroids, or aprotinin
12. Methylprednisolone inhibits increase of interleukin 8 and 6 during open heart surgery
13. Methylprednisolone and full-dose aprotinin reduce reperfusion injury after cardiopulmonary bypass
14. Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans
15. Aprotinin enhances the endogenous release of interleukin-10 after cardiac operations
16. Pump prime only aprotinin inhibits cardiopulmonary bypass-induced neutrophil CD11b upregulation