Inhibition of VRAC by c-Src tyrosine kinase targeted to caveolae is mediated by the Src homology domains

American Journal of Physiology - Cell Physiology

Volumn 281, Issue 1 50-1, 2001, Pages

  Trouet, Dominique ^a   Carton, Iris ^a   Hermans, Diane ^a   Droogmans, Guy ^a   Nilius, Bernd ^a   Eggermont, Jan ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Anion channel; Caveola; Cell volume; Tyrosine kinase; Volume regulated anion channel

Indexed keywords

ANION CHANNEL; CYSTEINE; PROTEIN TYROSINE KINASE INHIBITOR; SERINE;

ACYLATION; ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL VACUOLE; CELL VOLUME; CHLORIDE CURRENT; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT;

EID: 0034805343     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.281.1.c248     Document Type: Article

References (38)

1. Potocytosis: Sequestration and transport of small molecules by caveolae
2. The caveolae membrane system
3. ATP dependence of the I-Cl, I-swell channel varies with rate of cell swelling: Evidence for two modes of channel activation
4. Functions of lipid rafts in biological membranes
5. Regulation, substrates and functions of Src
6. Regulatory squelching
7. The Src family of protein tyrosine kinases: Regulation and functions
8. The volume-sensitive organic osmolyte-anion channel VSOAC is regulated by nonhydrolytic ATP binding
9. Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src
10. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases
11. Activation and suppression of pp60c-Src transforming ability by mutation of its primary sites of tyrosine phosphorylation
12. Early effects of pp60(v-Src) kinase activation on caveolae
13. Membrane microdomains and caveolae
14. The tyrosine kinase p56(lck) mediates activation of swelling-induced chloride channels in lymphocytes
15. Src tyrosine kinases, Gα subunits, and H-Ras share a common membrane- anchored scaf-folding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
16. Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains
17. Detergent-resistant membrane microdomains from Caco-2 cells do not contain caveolin
18. Properties of volume-regulated anion channels in mammalian cells
19. Activation of volume-regulated chloride currents by reduction of intracellular ionic strength in bovine endothelial cells
20. Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells
21. Tyrosine-phosphorylated caveolin-1: Immunolocalization and molecular characterization
22. - channel: Fresh start to the molecular identity and volume sensor
23. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane
24. Myristylation and palmitylation of Src family members: The fats of the matter
25. Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae
26. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae
27. Cysteine 3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae
28. Lipid rafts and signal transduction. Nature reviews
29. i1α) and c-Src tyrosine kinase to caveolae membranes: Clarifying the role of N-myristoylation
30. Tyrosine protein kinase inhibitors prevent activation of cardiac swelling-induced chloride current
31. Swelling-activated organic osmolyte efflux: A new role for anion channels
32. Cellular functions regulated by Src family kinases
33. Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances
34. Caveolin-1 modulates the activity of the volume-regulated chloride channel
35. Use of a bicistronic GFP-expression vector to characterise ion channels after transfection in mammalian cells
36. Rapid plasma membrane anchoring of newly synthesized p59fyn: Selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3
37. Reduced intracellular ionic strength as the initial trigger for activation of endothelial volume-regulated anion channels
38. Regulation of a swelling-activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins