Characterization of the phenotype and function of CD8+, α/β+ NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets

European Journal of Immunology

Volumn 31, Issue 9, 2001, Pages 2818-2828

  Stremmel, Christian ^a   Exley, Mark ^a   Balk, Steven ^b   Hohenberger, Werner ^a   Kuchroo, Vijay K ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

CD8; Cytotoxicity; Interleukin 4; NKT cell; Tumor

Indexed keywords

B7 ANTIGEN; CD8 ANTIGEN; CELL SURFACE MARKER; GAMMA INTERFERON; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL LINEAGE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HOST; IMMUNE SYSTEM; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOSURVEILLANCE; LYMPHOCYTE CULTURE; LYSIS; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TUMOR; TUMOR CELL;

ANIMALS; ANTIGENS; ANTIGENS, CD1; ANTIGENS, CD80; ANTIGENS, SURFACE; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; PROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH1 CELLS; TUMOR CELLS, CULTURED;

EID: 0034801661     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200109)31:9<2818::AID-IMMU2818>3.0.CO;2-1     Document Type: Article

References (30)

1. Mouse CD1d-specific NK1 T cells: Development, specificity, and function
2. A subset of CD4+ thymocytes selected by MHC class I molecules
3. - T cells in mice and humans
4. Dominant expression of a distinctive Vα14+ T-cell antigen receptor chain in mice
5. Murine thymic CD4+ T cell subsets: A subset (Thy0) that secretes diverse cytokines and overexpression the Vβ8 T cell receptor gene family
6. CD1 recognition by mouse NK1+ T lymphocytes
7. + T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
8. + T cells in a Th2 response and in immunoglobulin E production
9. Mouse NK1.1 + T cells
10. β2-microglobulin-dependent NK1.1 + T cells are not essential for T helper cell 2 immune responses
11. Immunoglobulin E production in the absence of IL-4-secreting CD1-dependent cells
12. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice
13. Interferon γ production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking
14. Requirements for CD1d recognition by human invariant Vα24 JαQ+ NKR-P1A+ T cells
15. + cells in the liver of mice
16. The CD1d family: A third lineage of antigen-presenting molecules
17. - T lymphocytes to a microbial antigen
18. + T cells
19. Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol
20. Peptide binding and presentation by mouse CD1
21. CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice
22. Diverse TCRs recognize murine CD1
23. Phenotypic characterization of CD8+ NKT cells
24. NKT cells are phenotypically and functionally diverse
25. Heterogeneity of NK1.1 + T cells in the bone marrow: Divergence from thymus
26. Tissue-specific segregation of CD1d-dependent and CD1d-independent NKT cells
27. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells
28. B7-2 expressed on EL4 lymphoma suppresses anti-tumor immunity by an IL-4 dependent mechanism
29. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors
30. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10