Shc mediates ligand-induced internalization of epidermal growth factor receptors

Biochemical and Biophysical Research Communications

Volumn 282, Issue 5, 2001, Pages 1154-1160

  Sakaguchi, Kazuhiko ^a   Okabayashi, Yoshinori ^a   Kasuga, Masato ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adaptin; AP2; EGF receptor; Endocytosis; Internalization; Shc

Indexed keywords

ADAPTIN; ADAPTOR PROTEIN; ALANINE; ALPHA ADAPTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; MEMBRANE PROTEIN; MUTANT PROTEIN; PHENYLALANINE; PIT ADAPTOR COMPLEX AP2; PROTEIN SHC; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADENOVIRUS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CYTOPLASM; GENE OVEREXPRESSION; HERPES SIMPLEX VIRUS; IMMUNOFLUORESCENCE; INTERNALIZATION; LIGAND BINDING; MEMBRANE VESICLE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

ADENOVIRIDAE; HERPES; SIMPLEXVIRUS;

EID: 0034801382     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4680     Document Type: Article

References (43)

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3. Dimerization of cell surface receptors in signal transduction
4. Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies
5. Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase
6. Signaling through scaffold, anchoring, and adaptor proteins
7. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
8. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins
9. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
10. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
11. Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells
12. Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells
13. Not all Shc's roads lead to Ras
14. Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc
15. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen (SHC) in chronic myelogenous leukemia progenitor cells
16. Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase
17. Src homologous and collagen (Shc) protein binds to F-actin and translocates to the cytoskeleton upon nerve growth factor stimulation in PC12 cells
18. Constitutive phosphorylation of eps8 in tumor cell lines: Relevance to malignant transformation
19. Interaction of the adaptor protein Shc and the adhesion molecule cadherin
20. Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc
21. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells
22. Interaction of Shc with adaptor protein adaptins
23. Clathrin and associated assembly and disassembly proteins
24. Clathrin, adaptors, and sorting
25. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
26. Endocytosis and signals for internalization
27. Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain
28. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor
29. Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr974-containing internalization motif
30. Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism
31. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain
32. Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins
33. The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
34. Differential utilization of ShcA tyrosine residues and functional domains in the transduction of epidermal growth factor-induced mitogen-activated protein kinase activation in 293T cells and nerve growth factor-induced neurite outgrowth in PC12 cells. Identification of a new Grb2.Sos1 binding site
35. Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation
36. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
37. Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes
38. Interaction of activated EGF receptors with coated pit adaptins
39. Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2
40. Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2
41. Association and colocalization of Eps15 with adaptor protein-2 and clathrin
42. Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits
43. Lysosomal targeting of epidermal growth factor receptors via a kinase-dependent pathway is mediated by the receptor carboxyl-terminal residues 1022-1123