The nuclear envelope in muscular dystrophy and cardiovascular diseases

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Volumn 2, Issue 10, 2001, Pages 675-683

  Burke, Brian ^a   Mounkes, Leslie C ^b   Stewart, Colin L ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cardiomyopathy; Emerin; Lamina associated polypeptides; Lipodystrophy; Muscular dystrophy; Nuclear envelope; Nuclear lamins; Nuclear membranes

Indexed keywords

EMERIN; LAMIN A; NUCLEAR PROTEIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ATRIOVENTRICULAR CONDUCTION; AUTOSOMAL DOMINANT DISORDER; CARDIOVASCULAR DISEASE; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELL STRUCTURE; CELL TYPE; CONTROLLED STUDY; DISEASE ASSOCIATION; EMBRYO; FAMILIAL DISEASE; GENETIC CODE; GENETIC DISORDER; HEART DILATATION; HEART MUSCLE; HEART MUSCLE CONDUCTION DISTURBANCE; HOUSEKEEPING GENE; LIMB GIRDLE MUSCULAR DYSTROPHY; LIPODYSTROPHY; MOUSE; MUSCULAR DYSTROPHY; NONHUMAN; OBSERVATION; PATHOLOGY; PRIORITY JOURNAL; REVIEW; SKELETAL MUSCLE; X CHROMOSOME;

ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; LAMINS; LIPODYSTROPHY; MUSCULAR DYSTROPHIES; MUTATION; NUCLEAR ENVELOPE; NUCLEAR PROTEINS;

EID: 0034799798     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.21001.x     Document Type: Review

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12. Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B
13. cDNA cloning of a germ cell-specific lamin B3 from mouse spermatocytes and analysis of its ectopic expression in somatic cells
14. An alternative splicing product of the lamin A/C gene lacks exon 10
15. Change of karyoskeleton during mammalian spermatogenesis: Expression pattern of nuclear lamin C2 and its regulation
16. The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope
17. The conserved carboxy-terminal cysteine of nuclear lamins is essential for association with the nuclear envelope
18. The CaaX motif is required for isoprenylation, carboxy methylation and nuclear membrane association of lamin B2
19. Maturation of nuclear lamin A involves a specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina
20. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein
21. Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR
22. HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics
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28. The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein
29. MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin
30. LAP2 binds to BAF.DNA complexes: Requirement for the LEM domain and modulation by variable regions
31. Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex
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37. Immunoelectron microscopic studies of the intracellular transport of the membrane glycoprotein (G) of vesicular stomatitis virus in infected Chinese hamster ovary cells
38. Direct interaction between emerin and lamin A
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48. Aberrant intracellular targeting and cell cycle-dependent phosphorylation of emerin contribute to the Emery-Dreifuss muscular dystrophy phenotype
49. The Emery-Dreifuss muscular dystrophy phenotype arises from aberrant targeting and binding of emerin at the inner nuclear membrane
50. Two distal mutations in the gene encoding emerin have profoundly different effects on emerin protein expression
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52. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy
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56. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease
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59. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy
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