Interleukin-10 is produced by human uterine natural killer cells but does not affect their production of interferon-γ

Molecular Human Reproduction

Volumn 7, Issue 10, 2001, Pages 971-977

  Vigano P ^a   Gaffuri, B ^a   Somigliana, E ^b   Infantino, M ^b   Vignali, M ^b   Di Blasio, A M ^a  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

IFN ; IL 10; Immune response; Pregnancy; Uterine NK cells

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 2; MESSENGER RNA;

ARTICLE; BLOOD PLACENTA BARRIER; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; CYTOTROPHOBLAST; ENDOMETRIUM; FEEDBACK SYSTEM; FEMALE; FETUS; FIRST TRIMESTER PREGNANCY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MOTHER; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; PREGNANCY; PRIORITY JOURNAL; PROTECTION; TH1 CELL; TH2 CELL; UTERUS;

CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; DECIDUA; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-2; KILLER CELLS, NATURAL; PREGNANCY; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-10; UTERUS;

EID: 0034795411     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity and uterine natural killer cell maturation during murine pregnancy
2. Interleukin-10 messenger ribonucleic acid in human placenta: Implications of a role for interleukin-10 in fetal allograft protection
3. IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-γ when combined with IL-18
4. The functional characterization of interleukin-10 receptor expression on human natural killer cells
5. IL-10 prevents naturally occuring fetal loss in the CBA×DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-τ
6. The emerging role of IL-10 in pregnancy
7. Production of IL-10 by melanoma cells: Examination of its role in immunosuppression mediated by melanoma
8. Cytokine-dependent abortion in CBA×DBA/2 mice is mediated by the procoagulant fg12 prothrombinase
9. Endometrial CD56+ natural killer cells in women with recurrent miscarriage: A histomorphometric study
10. Can murine uterine natural killer cells give insights into the pathogenesis of preeclampsia?
11. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-gamma production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
12. - Leucocyte clones from decidualized endometrium
13. IL-10 induces the tyrosine phosphorylation of Tyk2 and Jak1 and the differential assembly of STAT1α and STAT3 complexes in human T cells and monocytes
14. Malaria elicits type 1 cytokines in the human placenta: IFN-γ and TNF-α associated with pregnancy outcomes
15. Peripheral blood mononuclear cells stimulate progesterone production by luteal cells derived from pregnant women: Possible involvement of interleukin-4 and interleukin-10 in corpus luteum function and differentiation
16. Histochemical demonstration of interleukin-2 in decidual cells of patients with preeclampsia
17. A deficiency of placental IL-10 in preeclampsia
18. T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion
19. Differential effects of IL-4 and IL-10 on IL-2-induced IFN-γ synthesis and lymphokine-activated killer activity
20. A subset of CD56+ large granular lymphocytes in first-trimester human decidua are proliferating cells
21. Uterine leukocytes and decidualization
22. Human uterine lymphocytes
23. Stimulation of human decidual natural killer cells by interleukin-2 and stromal cells
24. HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells
25. Characteristic changes of large granular lymphocytes that strongly express CD56 in endometrium during the menstrual cycle and early pregnancy
26. T Helper 1 response against Leishmania Major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions
27. The role of T-helper cytokines in human reproduction
28. Synthesis of T helper 2-type cytokines at the maternal-fetal interface
29. Decidua in human implantation
30. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy
31. ++ large granular lymphocytes is amplified by decidual macrophages
32. Interleukin-12 and its free p40 subunit regulate immune recognition of endometrial cells: Potential role in endometriosis
33. Production of IL-10 by human natural killer cells stimulated with IL-12 and/or IL-12
34. Demonstration and functional analysis of IL-10 receptors in human epidermal cells: Decreased expression in psoriatic skin, down-modulation by IL-8, and up-regulation by an antipsoriatic glucocorticosteroid in keratinocytes
35. IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes
36. Properties and functions of interleukin-10
37. Interleukin-10 induction by IL-12: A possible modulatory mechanism?
38. Cutting edge: Differentiation of human NK cells into NK1 and NK2 subsets
39. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions
40. Pre-implantation endometrial leukocytes in women with recurrent miscarriage
41. Th1-type immunity is incompatible with successful pregnancy
42. Interleukin-10 attenuates experimental fetal growth restriction and demise
43. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin-10
44. Endometriosis and unexplained recurrent spontaneous abortion: Pathological states resulting from aberrant modulation of natural killer cell function?
45. Intercellular adhesion molecule (ICAM)-1 is expressed on human granulosa cells and mediates their interaction with lymphoid cells