An experiment of nature: Genetic L-arginine deficiency and NO insufficiency

Journal of Clinical Investigation

Volumn 108, Issue 5, 2001, Pages 663-664

  Loscalzo, J ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN; REACTIVE OXYGEN METABOLITE;

AMINO ACID DEFICIENCY; ENDOTHELIUM CELL; ENZYME SUBSTRATE; GENETIC DISORDER; HUMAN; HUMAN CELL; NOTE; PRIORITY JOURNAL; THROMBOCYTE FUNCTION; THROMBOSIS;

EID: 0034794736     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI13848     Document Type: Note

References (15)

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2. G-methylarginine
3. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
4. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells
5. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: Cultured endothelial cells recycle L-citrulline to L-arginine
6. Effects of in vivo and in vitro L-arginine supplementation on healthy human vessels
7. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans
8. Vascular endothelial dysfunction resulting from L-arginine deficiency in a patient with lysinuric protein intolerance
9. Reduced nitric oxide production by L-arginine deficiency in lysinuric protein intolerance exacerbates intravascular coagulation
10. Characterization of L-arginine uptake by plasma membrane vesicles isolated from cultured pulmonary artery endothelial cells
11. A calveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox"
12. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells
13. Nitric oxide insufficiency, platelet activation, and arterial thrombosis
14. Nitric oxide released from activated platelets inhibits platelet recruitment
15. Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide