Overexpression of GDNF induces and maintains hyperinnervation of muscle fibers and multiple end-plate formation

Experimental Neurology

Volumn 171, Issue 2, 2001, Pages 342-350

  Zwick, Melissa ^a   Teng, Lihong ^a   Mu, Xiaojun ^a   Springer, Joe E ^a   Davis, Brian M ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Glial cell line derived neurotrophic factor; Hyperinnervation; Motoneurons; Multiple end plates; Neuromuscular junctions; Target derived; Transgenic

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MYOSIN LIGHT CHAIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROCNEMIUS MUSCLE; HISTOCHEMISTRY; MOUSE; MUSCLE INNERVATION; NERVE CELL PLASTICITY; NERVE ENDING; NEUROMUSCULAR SYNAPSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SKELETAL MUSCLE; SPINAL CORD MOTONEURON; SPINAL GANGLION;

EID: 0034793857     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7753     Document Type: Article

References (40)

1. Neurotrophic factors in the therapy of peripheral neuropathy
2. Permanent rescue of lesioned neonatal motoneurons and enhanced axonal regeneration by adenovirus-mediated expression of glial cell-line-derived neurotrophic factor
3. The formation of synapses in striated muscle during development
4. Polyneuronal innervation of skeletal muscle in new-born rats and its elimination during maturation
5. GDNF is an age-specific survival factor for sensory and autonomic neurons
6. The determination of an empirical correction factor to deal with the problem of nucleolar splitting in neuronal counts
7. An empirical method for converting nucleolar counts to neuronal numbers
8. Accumulation of acetylcholine receptors at nerve-muscle contacts in culture
9. Over-expression of NGF in skin causes formation of novel sympathetic projections to trkA-positive sensory neurons
10. Rostrocaudal gradient of transgene expression in adult skeletal muscle
11. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
12. ARIA: A neuromuscular junction neuregulin
13. Early events in neuromuscular junction formation in vitro: Induction of acetylcholine receptor clusters in the postsynaptic membrane and morphology of newly formed synapses
14. Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system
15. Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse
16. Synaptic structure and development: The neuromuscular junction
17. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle
18. Motoneuron cell death in the developing lumbar spinal cord of the mouse
19. Physiology of the neurotrophins
20. Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons
21. IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life
22. Renal and neuronal abnormalities in mice lacking GDNF
23. Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle
24. The development of motoneurons in the embryonic spinal cord of the mouse mutant, muscular dysgenesis (mdg/mdg): Survival, morphology, and biochemical differentiation
25. Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
26. Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: Regulation of programmed cell death among motoneuron subtypes
27. A new stain for quantitative measurement of sprouting at neuromuscular junctions
28. Defects in enteric innervation and kidney development in mice lacking GDNF
29. The neuronal voltage-gated sodium channel, Scn8a, is essential for postnatal maturation of spinal, but not oculomotor, motor units
30. Elimination of synapses in the developing nervous system
31. Neuromuscular transmission in new-born rats
32. Myosin light chain enhancer activates muscle-specific, developmentally regulated gene expression in transgenic mice
33. Renal agenesis and the absence of enteric neurons in mice lacking GDNF
34. Localization of nerve growth factor receptor mRNA in the rat basal forebrain with in situ hybridization histochemistry
35. cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle
36. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS
37. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
38. Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3
39. Phenotypic and behavioral studies of transgenic mice that overexpress GDNF