Arginine 387 of human isovaleryl-CoA dehydrogenase plays a crucial role in substrate/product binding

Molecular Genetics and Metabolism

Volumn 74, Issue 1-2, 2001, Pages 226-237

  Volchenboum, Samuel L ^b   Mohsen, Al Walid A ^a   Kim, Jung Ja P ^c   Vockley, Jerry ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

ACD; Acyl CoA dehydrogenases; Catalytic site; Enzyme substrate complex; FAD; Isovaleric acidemia; Isovaleryl CoA dehydrogenase; Structure function analysis; Substrate binding

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; AMINO ACID; ARGININE; COENZYME A; FLAVOPROTEIN; GUANIDINE DERIVATIVE; ISOVALERY COENZYME A DEHYDROGENASE; OXYGEN; PANTETHEINE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SUBSTRATE; MOLECULAR MODEL; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION;

EID: 0034793086     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2001.3234     Document Type: Article

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