Cadmium affects the redox state of rat liver glucocorticoid receptor

Cell Biology and Toxicology

Volumn 17, Issue 3, 2001, Pages 169-177

  Elez, D ^a   Dundjerski, J ^a   Matic G ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Cadmium; Disulfide bonds; Glucocorticoid receptor; Hsp70; Hsp90; Sulfhydryl groups

Indexed keywords

CADMIUM; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HYDROGEN PEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISULFIDE BOND; DNA BINDING; IMMUNOBLOTTING; LIVER CYTOSOL; MALE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

ANIMALS; CADMIUM; CYTOSOL; DISULFIDES; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HYDROGEN PEROXIDE; LIVER; MALE; OXIDANTS; OXIDATION-REDUCTION; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID;

ANIMALIA;

EID: 0034792826     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011940414419     Document Type: Article

References (34)

1. Protection against cadmium toxicity and enzyme inhibition by dithiothreitol
2. Inhibition of glucocorticoid receptor transformation, subunit dissociation, and temperature-dependent inactivation by various N-substituted maleimides
3. Sulfhydryl-modifying reagents reversibly inhibit binding of glucocorticoid-receptor complexes to DNA-cellulose
4. Evidence for distinct sulfhydryl groups associated with steroid- and DNA-binding domains of rat thymus glucocorticoid receptors
5. Hydrogen peroxide stabilizes the steroid-binding state of rat liver glucocorticoid receptors by promoting disulfide bond formation
6. Evidence that the 90 kDa heat shock protein is necessary for the steroid binding conformation of the L-cell glucocorticoid receptor
7. Role of cysteines 640, 656 and 661 in steroid binding to rat glucocorticoid receptors
8. Association of the rat liver glucocorticoid receptor with Hsp90 and Hsp70 upon whole body hyperthermic stress
9. Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition
10. Molecular chaperones and subcellular trafficking of steroid receptors
11. In vivo effects of cadmium on rat liver glucocorticoid receptor functional properties
12. Cadmium affects the activity of rat liver tyrosine amino-transferase and its induction by dexamethasone
13. Heat shock alters the composition of heteromeric steroid-receptor complexes and enhances receptor activity in vivo
14. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain
15. Evidence that the endogenous heat stable glucocorticoid receptor activating factor is thioredoxin
16. Proof that the endogenous heat-stable glucocorticoid receptor activating factor is thioredoxin
17. Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor
18. 4
19. Study of the heteromeric structure of the untransformed glucocorticoid receptor using chemical cross-linking and monoclonal antibodies against the 90 K heat shock protein
20. Protein measurement with the Folin phenol reagent
21. Thioredoxin: A redox-reguating cellular cofactor for glucocorticoid hormone action, cross-talk between endocrine control of stress response and cellular antioxidant defense system
22. Selective molybdate-directed covalent modification of sulfhydryl groups in the steroid-binding versus DNA-binding domain of the glucocorticoid receptor
23. Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA
24. Absence of intramolecular disulfides in the structure and function of native rat glucocorticoid receptors
25. The Hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factors
26. Steroid receptor interactions with heat shock protein and immunophilin chaperones
27. Direct evidence for intra- and intermolecular disulfide bond formation in the human glucocorticoid receptor
28. Identification of cysteine 656 as the amino acid of hepatoma tissue culture cell glucocorticoid receptors that is covalently labeled by dexamethasone 21-mesylate
29. Arsenite and cadmium (II) as probes of glucocorticoid receptor structure and function
30. Identification of cysteine 644 as the covalent site of attachment of dexamethasone 21-mesylate to murine glucocorticoid receptor in WEHI-7 cells
31. The role of sulfhydryl groups in permitting transformation and DNA binding of the glucocorticoid receptor
32. Involvement of sulfhydryl metabolism in tolerance to cadmium in testicular cells
33. Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation
34. 2+ sequestering