Acetylcholinesterase inhibitor SDZ ENA 713 (Rivastigmine) increases brain pyrrolidone carboxyl peptidase activity

European Neuropsychopharmacology

Volumn 11, Issue 5, 2001, Pages 381-383

  Ramírez Expósito, María Jesús ^a   Robert Baudouy, Janine ^b   Mayas, María Dolores ^a   García, María Jesús ^a   Ramírez, Manuel ^a   Martínez Martos, José Manuel ^a  

^a UNIVERSITY OF JAÉN   (Spain)

^b CNRS   (France)

Author keywords

Amyloid; Pyrrolidone carboxyl peptidase; Rivastigmine

Indexed keywords

5 OXOPROLYL PEPTIDASE; AMYLOID BETA PROTEIN; BRAIN ENZYME; POTASSIUM ION; PYRROLIDONE CARBOXYL PEPTIDASE; RIVASTIGMINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CHOLINERGIC TRANSMISSION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FRONTAL CORTEX; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENILE PLAQUE; STIMULATION;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CARBAMATES; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; MALE; MICE; MICE, INBRED BALB C; PHENYLCARBAMATES; PREFRONTAL CORTEX; PYROGLUTAMYL-PEPTIDASE I; SYNAPTOSOMES;

EID: 0034791327     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(01)00106-7     Document Type: Article

References (11)

1. Pyrrolidone carboxyl peptidase (Pcp): An enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins
2. The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater β-sheet forming and aggregation propensities in vitro than full-length Aβ
3. Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease
4. Hypothesis: Amyloid β-peptides truncated at the N-terminus contribute to the pathogenesis of Alzheimer's disease
5. Molecular basis of the neurodegenerative disorders
6. Human serum pyroglutamyl-β-naphthylamide hydrolyzing activity during development and aging
7. +- and ATP-stimulated rodent cortex synaptosomes
8. Alzheimer's disease as proteolytic disorders: Anabolism and catabolism of β-amyloid
9. Dominant and differential deposition of distinct β-amyloid peptide species, A betaN3(pE), in senile plaques
10. Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain
11. 14C]SDZ ENA 713, an acetylcholinesterase inhibitor, in minipigs following oral, intravenous and dermal administration