Absence of t(12;15) associated ETV6-NTRK3 fusion transcripts in pediatric acute leukemias

Medical and Pediatric Oncology

Volumn 37, Issue 4, 2001, Pages 415-416

  Alessandri, Angela J ^a   Knezevich, Stevan R ^a   Mathers, Joan A ^b   Schultz, Kirk R ^a   Sorensen, Poul H B ^a,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c CHILDREN S AND WOMEN S HEALTH CENTRE OF BRITISH COLUMBIA   (Canada)

Author keywords

ETV6 NTRK3; Pediatric leukemia; RT PCR; t(12; 15) translocation

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 12; CHROMOSOME 15; CHROMOSOME 21; CHROMOSOME 6; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 15; CONTROLLED STUDY; FEMALE; GENE FUSION; HUMAN; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 15; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS C-ETS; RECEPTOR, TRKC; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SENSITIVITY AND SPECIFICITY;

EID: 0034788794     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/mpo.1222     Document Type: Article

References (11)

1. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5:12) chromosomal translocation
2. Molecular genetics of childhood leukemias
3. The role of TEL fusion genes in pediatric leukemias
4. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma
5. ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenic link between mesoblastic nephroma and congenital fibrosarcoma
6. Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: Cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma
7. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells
8. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25)
9. A unique translocation of the TEL gene in a case of acute myelogenous leukemia with inv(12)(p13q15)
10. Signal transduction and transforming properties of TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia
11. Detection of the EWS/WTI gene fusion by reverse transcriptase-polymerase chain reaction in the diagnosis of intra-abdominal desmoplastic small round cell tumor