Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex

Neuropharmacology

Volumn 41, Issue 6, 2001, Pages 762-770

  Philpot, Benjamin D ^a   Weisberg, Michael P ^a   Ramos, Margarita S ^a   Sawtell, Nathaniel B ^a   Tang, Ya Ping ^b   Tsien, Joe Z ^b   Bear, Mark F ^a  

^a BROWN UNIVERSITY   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

Cortical plasticity; Critical period; LTP; Metaplasticity; NMDA receptor; NR2B

Indexed keywords

MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EVOKED VISUAL RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE OVEREXPRESSION; HIPPOCAMPUS; MOUSE; NERVE CELL PLASTICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PYRAMIDAL NERVE CELL; STIMULATION; TEMPORAL SUMMATION; TRANSGENE; TRANSGENIC MOUSE; VISUAL CORTEX;

ANIMALS; EXCITATORY POSTSYNAPTIC POTENTIALS; LONG-TERM POTENTIATION; MICE; MICE, TRANSGENIC; NEURONAL PLASTICITY; PYRAMIDAL CELLS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES; SYNAPTOSOMES; VISUAL CORTEX;

EID: 0034788733     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00136-8     Document Type: Article

References (32)

1. NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses
2. Mechanism for a sliding synaptic modification threshold
3. A physiological basis for a theory of synaptic modification
4. Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist
5. Synaptic plasticity: LTP and LTD
6. Theory for the development of neuron selectivity: Orientation specificity and binocular interaction in visual cortex
7. Reversal of the physiological effects of monocular deprivation in kittens: Further evidence for a sensitive period
8. Activity-dependent decrease in NMDA receptor responses during development of the visual cortex
9. Architectonic map of neocortex of the normal mouse
10. Developmental changes in the expression of NMDA receptor subunits (NR1, NR2A, NR2B) in the cat visual cortex and the effects of dark rearing
11. NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex
12. Experience-dependent plasticity of binocular responses in the primary visual cortex of the mouse
13. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
14. The development of pyramidal neurons after eye opening in the visual cortex of hooded rats: A quantitative study
15. Experience-dependent modification of synaptic plasticity in visual cortex
16. N-methyl-D-aspartic acid receptor structure and function
17. Chronic recordings from single sites of kitten striate cortex during experience-dependent modifications of receptive-field properties
18. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
19. Genetic and epigenetic regulation of NMDA receptor expression in the rat visual cortex
20. Metaplasticity: The plasticity of synaptic plasticity
21. Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex
22. Effects of early visual experience and diurnal rhythms on BDNF mRNA and protein levels in the visual system, hippocampus, and cerebellum
23. The visual physiology of the wild type mouse determined with pattern VEPs
24. Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development
25. Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo
26. Monocular deprivation induces homosynaptic long-term depression in visual cortex
27. Suppression of NMDA receptor function using antisense DNA block ocular dominance plasticity while preserving visual responses
28. Enhanced NR2A subunit expression and decreased NMDA receptor decay time at the onset of ocular dominance plasticity in the ferret
29. Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons
30. Genetic enhancement of learning and memory in mice
31. Genetic enhancement of inflammatory pain by forebrain NR2B overexpression
32. Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens