Suppression of NMDA receptor function using antisense DNA blocks ocular dominance plasticity while preserving visual responses

Journal of Neurophysiology

Volumn 80, Issue 3, 1998, Pages 1021-1032

  Roberts, Elizabeth B ^a   Meredith, M Alex ^a   Ramoa, Ary S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENTARY DNA; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN SLICE; CONTROLLED STUDY; EYE DOMINANCE; FERRET; HEMISPHERIC DOMINANCE; HISTOGRAM; MONOCULAR DEPRIVATION; NERVE CELL PLASTICITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; VISION; VISUAL CORTEX;

EID: 0031731815     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.80.3.1021     Document Type: Article

References (42)

1. AGRAWAL, S. Antisense Therapeutics. Clifton, NJ: Humana, 1996.
2. BEAR, M. F., COOPER, L. N., AND EBNER, F. F. A physiological basis for a theory of synapse modification. Science 237: 42-48, 1987.
3. BEAR, M. F., KLEINSCHMIDT, A., Gu, Q., AND SINGER, W. Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist. J. Neurosci. 10: 909-925, 1990.
4. BIENENSTOCK, E. L., COOPER, L. N., AND MUNRO, P. W. Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J. Neurosci. 2: 32-48, 1982.
5. BLANTON, M. G., LOTURCO, J. L., AND KRIEGSTEIN, A. R. Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex. J. Neurosci. Methods 30: 203-210, 1989.
6. BOURNE, H. R. AND NICOLL, R. Molecular machines integrate coincident synaptic signals. Cell 72, Neuron 70, Suppl.: 65-75, 1993.
7. BROSE, N., HUNTLEY, G. W., STERN-BACH, Y., SHARMA, G., MORRISON, J. H., AND HEINEMANN, S. F. Differential assembly of coexpressed glutamate receptor subunits in neurons of rat cerebral cortex. J. Biol. Chem. 269: 16780-16784, 1994.
8. CATALANO, S. M., CHANG, C. K., AND SHATZ, C. J. Activity-dependent regulation of NMDAR1 immunoreactivity in the developing visual cortex. J. Neurosci. 17: 8376-8390, 1997.
9. CHAPMAN, B. AND STRYKER, M. P. Development of orientation selectivity in ferret visual cortex and effects of deprivation. J. Neurosci. 13: 5251-5262, 1993.
10. CHAPMAN, B., ZAHS, K. R., HARRIS, S. L., AND STRYKER, M. P. Plasticity following monocular deprivation in ferret primary visual cortex. Soc. Neurosci. Abstr. 22: 1729, 1996.
11. CONSTANTINE-PATON, M., CLINE, H. T., AND DEBSKI, E. Patterned activity, synaptic convergence and the NMDA receptor in developing visual pathways. Annu. Rev. Neurosci. 13: 129-154, 1990.
12. DAW, N. W. Mechanisms of plasticity in the visual cortex. Invest. Ophthalmol. Vis. Sci. 35: 4168-4179, 1994.
13. EVANS, R. H., FRANCIS, A. A., JONES, A. W., SMITH, D.A.S., AND WATKINS, J. C. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br. J. Pharmacol. 75: 65-75, 1982.
14. Fox, K. AND DAW, N. W. Do NMDA receptors have a critical function in visual cortical plasticity? Trends Neurosci. 16: 116-122, 1993.
15. Fox, K., SATO, H., AND DAW, N. The location and function of NMDA receptors in cat and kitten visual cortex. J. Neurosci. 9: 2443-2454, 1989.
16. Fox, K., SATO, H., AND DAW, N. W. The effect of varying stimulus intensity on NMDA-receptor activity in cat visual cortex. J. Neurophysiol. 64: 1413-1428, 1990.
17. HEBB, D. O. The Organization of Behavior. New York: Wiley, 1949.
18. HUBEL, D.H., WIESEL, T. N., AND LEVAY, S. Plasticity of ocular dominance columns in the monkey striate cortex. Philos. Trans. R. Soc. Lond. B Biol. Sci. 278: 377-409, 1977.
19. ISHII, T., MORIYOSHI, K., SUGIHARA, H., SAKURADA, K., KADOTANI, H., YOKOI, M., AKAZAWA, C., SHIGEMOTO, R., MIZUNO, N., MASU, M., AND NAKANISHI, S. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268: 2836-2843, 1993.
20. JONES, A. W., SMITH, D. A., AND WATKINS, J. C. Structure-activity relations of dipeptide antagonists of excitatory amino acids. Neuroscience 13: 573-581, 1984.
21. KASAMATSU, T., IWAMMA, K., MATAGA, N., HARTVEIT, E., HEGGELUND, U., AND HEGGELUND, P. Roles of N-methyl-D-aspartate receptors in ocular dominance plasticity in developing visual cortex: re-evaluation. Neuroscience 82: 687-700, 1998.
22. KATZ, L. G. AND SHATZ, C. J. Synaptic activity and the construction of cortical circuits. Science 274: 1133-1138, 1996.
23. KUTSUWADA, T., KASHIWABUCHI, N., MORI, H., SAKIMURA, K., KUSHIYA, E., ARAKI, K., MEGURO, H., MASAKI, H., KUMANISHI, T., ARAKAWA, M., AND MISHINA, M. Molecular diversity of the NMDA receptor channel. Nature 358: 36-41, 1992.
24. LAURIE, D. J. AND SEEBURG, P. H. Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J. Neurosci. 14: 3180-3194, 1994.
25. LEVICK, W. R. Another tungsten microelectrode. Med. Electron. Biol. Eng. 10: 510-515, 1972.
26. MACDERMOTT, A. B., MAYER, M. L., WESTBROOK, G. L., SMITH, S. J., AND BARKER, J. L. NMDA receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321: 519-522, 1986.
27. ++ of NMDA responses in spinal cord neurones. Nature 309: 261-263, 1984.
28. MEGURO, H., MORI, H., ARAKI, K., KUSHIYA, E., KUTSUWADA, T., YAMAZAKI, M., KUMANISHI, T., ARAKAWA, M., SAKIMURA, K., AND MISHINA, M. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357: 70-74, 1992.
29. MILLER, K. D., CHAPMAN, B., AND STRYKER, M. P. Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. USA 86: 5183-5187, 1989.
30. MONYER, H., SPRENGEL, R., SCHOEPFER, R., HERB, A., HIGUCHI, M., LOMELI, H., BURNASHEV, N., SAKMANN, B., AND SEEBERG, P. H. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256: 1217-1221, 1992.
31. MORIYOSHI, K., MASU, M., SHII, T., SHIGEMOTO, R., MIZUNO, N., AND NAKANISHI, S. Molecular cloning and characterization of the rat NMDA receptor. Nature 354: 31-37, 1991.
32. NAKANISHI, N., AXEL, A., AND SCHNEIDER, N. A. Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. USA 89: 8552-8556, 1992.
33. NOWAK, R., BREGESTOVSKI. P., ASCHER, P., HERBERT, A., AND PROCHIANTZ, A. Magnesium gates glutamate-activated channels in mouse central neurons. Nature 307: 462-465, 1984.
34. PETRALIA, R. S., WANG, Y. X., AND WENTHOLD, R. J. The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1. J. Neurosci. 14: 6102-6120, 1994.
35. RAMOA, A. S., ALKONDON, M., ARACAVA, Y., IRONS, J., LUNT, G. G., DESHPANDE, S. S., WONNACOTT, S., AND ALBUQUERQUE, E. X. The anticonvulsant MK-801 blocks the peripheral and central nicotinic acetylcholine receptor ion channels. J. Pharmacol. Exp. Ther. 254: 71-82, 1990.
36. RAMOA, A. S. AND MCCORMICK, D. A. Developmental changes in electrophysiological properties of LGNd neurons during reorganization of retinogeniculate connections. J. Neurosci. 14: 2089-2097, 1994.
37. RAMOA, A. S., PARADISO, M. A., AND FREEMAN, R. D. Blockade of intracortical inhibition in kitten striate cortex. Effects on receptive field properties and associated loss of ocular dominance plasticity. Exp. Brain Res. 73: 285-296, 1988.
38. RAUSCHECKER, J. P., EGERT, V., AND KOSSEL, A. Effects of NMDA antagonists on developmental plasticity in kitten visual cortex. Int. J. Dev. Neurosci. 8: 425-435, 1990.
39. STENT, G. S. A physiological mechanism for Hebb's postulate of learning. Proc. Natl. Acad. Sci. USA 70: 997-1001, 1973.
40. WAHLESTEDT, C. Antisense oligonucleotide strategies in neuropharmacology. Trends Pharmacol. Sci. 15: 42-46, 1994.
41. WAHLESTEDT, C., GOLANOV, E., YAMAMOTO, S., YEE, F., ERICSON, H., Yoo, H., INTURRISI, C. E., AND REIS, D. J. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature 363: 260-263, 1993.
42. WIESEL, T. N. AND HUBEL, D. Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens. J. Neurophysiol. 28: 1029-1040, 1965.