CNQX increases GABA-mediated synaptic transmission in the cerebellum by an AMPA/kainate receptor-independent mechanism

Neuropharmacology

Volumn 41, Issue 6, 2001, Pages 730-736

  Brickley, S G ^a   Farrant, M ^a   Swanson, G T ^b   Cull Candy, S G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

GABAA receptors; Golgi cell; Granule cell; IPSCs; Quinoxaline derivatives

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 2 AMINO 5 PHOSPHONOVALERIC ACID; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; 6,7 DINITRO 2,3 QUINOXALINEDIONE; 6,7,8,9 TETRAHYDRO 5 NITROBENZ[G]INDOLE 2,3 DIONE 3 OXIME; 7 CHLOROKYNURENIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; IONOTROPIC RECEPTOR; KAINIC ACID RECEPTOR ANTAGONIST; KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; QUINOXALINE DERIVATIVE; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; GRANULE CELL; HIPPOCAMPUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; CEREBELLUM; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; MICE; PRESYNAPTIC TERMINALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, GABA-A; RECEPTORS, GLUTAMATE; RECEPTORS, KAINIC ACID; SYNAPTIC TRANSMISSION;

EID: 0034788332     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00135-6     Document Type: Article

References (32)

1. Kainate receptors regulate unitary IPSCs elicited in pyramidal cells by fast-spiking interneurons in the neocortex
2. Effects of new non-N-methyl-D-aspartate antagonists on synaptic transmission in the in vitro rat hippocampus
3. 6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus
4. Neuropharmacology of AMPA and kainate receptors
5. Kainate receptors are involved in synaptic plasticity
6. A receptors
7. A receptor-mediated synaptic currents in granule cells of the rat cerebellum
8. A receptors suggest differential targeting of receptor subtypes
9. Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
10. Potentiation of GABAergic synaptic transmission by AMPA receptors in mouse cerebellar stellate cells: Changes during development
11. Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons
12. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission
13. Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons
14. The glutamate receptor ion channels
15. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses
16. Synaptic kainate receptors
17. Presynaptic effects of NMDA in cerebellar Purkinje cells and interneurons
18. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists
19. A Kainate receptor increases the efficacy of GABAergic synapses
20. Molecular physiology of kainate receptors
21. Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site
22. Presynaptic ionotropic receptors and the control of transmitter release
23. Heterogeneous susceptibility of GABA(A) receptor-mediated IPSCs to depolarization-induced suppression of inhibition in rat hippocampus
24. CNQX increases spontaneous inhibitory input to CA3 pyramidal neurones in neonatal rat hippocampal slices
25. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro
26. Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons
27. Comparative antagonism of kainate-activated kainate and AMPA receptors in hippocampal neurons
28. Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus
29. Synaptic activation of AMPA receptors inhibits GABA release from cerebellar interneurons
30. The Ca(v)2.1/alpha 1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells
31. Development of action potential-dependent and independent spontaneous GABAA receptor-mediated currents in granule cells of postnatal rat cerebellum
32. Differential antagonism of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines