A double-blind study to evaluate the safety of recombinant human hemoglobin in surgical patients during general anesthesia

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 15, Issue 5, 2001, Pages 593-602

  Hayes, John K ^a,b   Stanley, Theodore H ^a,b   Lind, Gregar H ^a,b   East, Katherine ^a,b   Smith, Barbara ^a,b   Kessler, Karen ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Anesthesia; Blood; Hemoglobin; Recombinant; Red cell substitutes; Safety; Transfusion

Indexed keywords

AMYLASE; BILIRUBIN; CREATININE; HEMOGLOBIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RECOMBINANT HEMOGLOBIN; SODIUM CHLORIDE; TRIACYLGLYCEROL LIPASE; UREA;

ADULT; ANTIBODY TITER; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD LEVEL; BLOOD TRANSFUSION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GENERAL ANESTHESIA; HEMATOCRIT; HUMAN; HYPERTENSION; KIDNEY FUNCTION; LEUKOCYTE COUNT; LIVER FUNCTION; MALE; PANCREAS FUNCTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETICULOCYTE COUNT; SAFETY; UREA NITROGEN BLOOD LEVEL;

EID: 0034782814     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/jcan.2001.26538     Document Type: Article

References (30)

1. Transfusion-associated bacterial sepsis: The phoenix rises yet again
2. Blood transfusion-induced immunomodulation
3. The relationship of blood transfusion, tumor staging, and cancer recurrence
4. Collection and transfusion of blood and blood components in the United States
5. Clinical development of perfluorocarbon-based emulsions as red cell substitutes in blood substitutes
6. Introduction overview and perspectives
7. The linkage between oxygenation and subunit dissociation in human hemoglobin
8. The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin
9. Blood substitutes: Physiological basis of efficacy
10. A human recombinant haemoglobin designed for use as a blood substitute
11. Expression of fully functional tetrameric human hemoglobin in Escherichia coli
12. Synthesis of wild type and mutant human hemoglobins in Saccharomyces cerevisiae
13. Hemoglobin Presbyterian: Beta 108(G10) asparagine leads to lysine, a hemoglobin variant with low oxygen affinity
14. Structures of hemoglobin-based blood substitute: Insights into the function of allosteric proteins
15. Preclinical biology of recombinant human hemoglobin, rHb1.1
16. Use of recombinant hemoglobin solution in reversing lethal hemorrhagic hypovolemic oxygen debt shock
17. Recombinant human hemoglobin designed for use as an oxygen delivering therapeutic
18. Recombinant human hemoglobin does not affect renal function in humans: Analysis of safety and pharmacokinetics
19. Resuscitation after hemorrhage using recombinant human hemoglobin (rHb1.1) in rats: Effects on nitric oxide and prostanoid systems
20. Efficacy of recombinant human hemoglobin to restore oxygen consumption following hemorrhage
21. Recombinant human hemoglobin (rHb1.1) selectively inhibits vasorelaxation elicited by nitric oxide donors in rabbit isolated aortic rings
22. Norepinephrine release during vasoconstriction induced by cross-linked hemoglobin
23. A role for endothelin and nitric oxide in the pressor response to diaspirin cross-linked hemoglobin
24. Endothelial modulation of contractions caused by oxyhemoglobin and NG-nitro-L-arginine in isolated dog and monkey cerebral arteries
25. The contribution of pancreas and kidney in regulating serum amylase levels in dogs
26. In vivo and in vitro influence of human recombinant hemoglobin on esophageal function
27. The effects of recombinant human hemoglobin on esophageal function in humans
28. Effects of recombinant human hemogloblin on opossum sphincter of Oddi motor function in vivo and in vitro
29. Role of nitric oxide in esophageal peristalsis in the opossum