Has melatonin a future as a cardioprotective agent?

Cardiovascular Drugs and Therapy

Volumn 15, Issue 3, 2001, Pages 205-207

  Duncker, D J ^a   Verdouw, P D ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MELATONIN; SCAVENGER;

ANTIARRHYTHMIC ACTIVITY; ANTIOXIDANT ACTIVITY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; EDITORIAL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; CARDIOTONIC AGENTS; CRICETINAE; MELATONIN; MYOCARDIAL REPERFUSION INJURY; RATS;

EID: 0034781607     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011903904056     Document Type: Editorial

References (19)

1. Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo
2. Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation
3. Melatonin affords protection against gastric lesions induced by ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effects
4. Regulation of gastric mucosal integrity by endogenous nitric oxide: Interactions with prostanoids and sensory neuropeptides in the rat
5. Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia
6. Protective effect of melatonin on antioxidative system in experimental ischemia-reperfusion of rat small intestine
7. Central serotonergic agents raise the repetitive extrasystole threshold of the vulnerable period of the canine ventricular myocardium
8. Neurochemical approaches to the prevention of ventricular fibrillation
9. Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: Prevention by melatonin
10. Melatonin scavenges hydroxyl radical and protects isolated rat hearts from ischemic reperfusion injury
11. Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart
12. Oxygen-derived free radicals and myocardial reperfusion injury: An overview
13. The effect of melatonin on hemodynamics, blood flow, and myocardial infarct size in a rabbit model of ischemia-reperfusion
14. Melatonin protects against ischaemic-reperfusion myocardial damage
15. Effects of melatonin on injury produced by ischemia and reperfusion injury of the rat heart
16. Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease
17. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes
18. + channels triggers the preconditioned state by generating free radicals
19. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism