Do ethanol and deuterium oxide distribute into the same water space in healthy volunteers?

Alcoholism: Clinical and Experimental Research

Volumn 25, Issue 10, 2001, Pages 1423-1430

  Norberg, Åke ^a   Sandhagen, Bo ^b   Bratteby, Lars Eric ^b   Gabrielsson, Johan ^c   Jones, Alan Wayne ^d   Fan, Hu ^b   Hahn, Robert G ^e  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^e STOCKHOLM SÖDER HOSPITAL   (Sweden)

Author keywords

Ethanol Pharmacokinetics; Healthy Volunteers; Multicompartment Model; Nonlinear Kinetics; Total Body Water

Indexed keywords

ALCOHOL; DEUTERIUM OXIDE;

ADULT; ALCOHOL BLOOD LEVEL; ARTICLE; BREATH ANALYSIS; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG ELIMINATION; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MICHAELIS MENTEN KINETICS; NORMAL HUMAN; PRIORITY JOURNAL; TOTAL BODY WATER;

EID: 0034781058     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2001.tb02143.x     Document Type: Article

References (43)

1. Ranitidine increases the bioavailability of imbibed alcohol by accelerating gastric emptying
2. Statistical methods for assessing agreement between two methods of clinical measurement
3. Sources of error in bioimpedance spectroscopy
4. Total energy expenditure and physical activity as assessed by the doubly labeled water method in Swedish adolescents in whom energy intake was underestimated by 7-day diet records
5. A mechanistic view of the nonideal osmotic and motional behavior of intracellular water
6. Measuring total body water in peritoneal dialysis patients using an ethanol dilution technique
7. The blood/breath ratio of ethanol
8. Blood ethanol levels following rapid intravenous infusion
9. The measurement of breath alcohol. The laboratory evaluation of substantive breath test equipment and the report of an operational police trial
10. 2O and ethanol dilutions in total body water measurements in humans
11. Determination and prediction of tissue-gas partition coefficients
12. Determinants and analysis of blood alcohol concentrations after social drinking
13. Bestimmung des körperwassergehaltes mit hilfe von alkohol
14. Statistical evaluation and reporting of blood alcohol/ breath ratio distribution data
15. Human body composition: Advances in models and methods
16. Distribution of ethanol: Plasma to whole blood ratios
17. Clinical pharmacokinetics of ethanol
18. Role of hydration and water structure in biological and colloidal interactions
19. Distribution of ethanol and water between plasma and whole blood; inter- and intraindividual variations after administration of ethanol by intravenous infusion
20. Pharmacokinetics of ethanol in plasma and whole blood: Estimation of total body water by the dilution principle
21. Concentration-time profiles of ethanol in arterial and venous blood and end-expired breath during and after intravenous infusion
22. Computer-aided headspace gas chromatography applied to blood-alcohol analysis: Importance of online process control
23. Pharmacokinetics of ethanol: Absorption, distribution, and elimination
24. Partition coefficients of some acetate esters and alcohols in water, blood, olive oil, and rat tissues
25. Total body water and lean body mass estimated by ethanol dilution
26. The kinetics of alcohol elimination in man
27. The pharmacokinetics of alcohol in human breath, venous and arterial blood after oral ingestion
28. Improved estimation of tissue hydration and bound water fraction in rat liver tissue
29. Within- and between-subject variations in pharmacokinetic parameters of ethanol by analysis of breath, venous blood and urine
30. First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying
31. The determination of total body water in man with ethanol dilution
32. 18O-labeled water in humans
33. Ethanol 'dose -dependent' elimination: Michaelis-Menten v classical kinetic analysis
34. Brain self-stimulation, locomotor activity and tissue concentrations of ethanol in male rats
35. Update: NIH consensus conference. Bioelectrical impedance analysis for the measurement of human body composition: Where do we stand and what is the next step?
36. Concentrations of ethanol in two segments of the vascular system
37. Distribution volume of ethanol as a measure of body water
38. Aging and ethanol metabolism
39. Measurement of total body water in patients on maintenance hemodialysis using an ethanol dilution technique
40. Comparison of plasma, serum, and whole blood ethanol concentrations