Concentration-time profiles of ethanol in arterial and venous blood and end-expired breath during and after intravenous infusion

Journal of Forensic Sciences

Volumn 42, Issue 6, 1997, Pages 1088-1094

  Jones, A W ^a,b,c   Norberg, A ^a,b,c   Hahn, R G ^a,b,c  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b STOCKHOLM SÖDER HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

A V difference; Alcohol; Analysis; Arterial blood; Breath; Forensic science; Pharmacokinetics; Venous blood

Indexed keywords

ABSORPTION; ADULT; ALCOHOL BLOOD LEVEL; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; BREATH ANALYSIS; CLINICAL ARTICLE; CONCENTRATION RESPONSE; FORENSIC SCIENCE; GAS CHROMATOGRAPHY; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0030720061     PISSN: 00221198     EISSN: None     Source Type: Journal    
DOI: 10.1520/jfs14265j     Document Type: Article

References (28)

1. Harger RN, Hulpieu HR, Lamb EB. The speed with which various parts of the body reach equilibration in the storage of ethyl alcohol. J Biol Chem 1937;120:689-704.
2. Forney RB, Hulpieu HR, Harger RN. The levels of alcohol concentration in brain, peripheral blood and heart blood ten minutes after oral administration. J Pharmacol 1950;98:8-9.
3. Sunahara GL, Kalant H, Schofield M, Grupp L. Regional distribution of ethanol in the rat brain. Can J Physiol Pharmacol 1978;56:988-92.
4. Garriott JC. (editor) Medicolegal aspects of alcohol. 3rd edition, Lawyers & Judges Publishing Co, Tucson, 1996;1-526.
5. Mellanby E. Alcohol; Its absorption into an disappearance from the blood stream under different conditions. British medical research council special report, Series no 31, HMSO, London, 1919.
6. Jones AW. Measuring alcohol in blood and breath for forensic purposes; A historical review. Forensic Sci Rev 1996;8:14-44.
7. Martin CS, Earleywine M. Ascending and descending rates of change in blood alcohol concentrations and subjective intoxication rates. J Sub Abuse 1990;2:345-52.
8. Martin CS, Moss HB. Measurement of acute tolerance to alcohol in human subjects. Alcoholism Clin Exp Res 1993;17:211-6.
9. Gumbleton M, Oie S, Verotta D. Pharmacokinetic pharmacodynamic (PK-PD) modelling in non-steady-state studies and arteriovenous drug concentration differences. Br J Clin Pharmacol 1994;38:389-400.
10. Jones AW. Enforcement of drink driving laws by use of "per se" legal alcohol limits; Blood and/or breath concentration as evidence of impairment. Alc Drugs Driving 1988;4:99-112.
11. Jones AW. Physiological aspects of breath-alcohol measurements. Alc Drugs Driving 1990;6:1-25.
12. Harger RN, Forney RB, Barnes HB. Estimation of the level of blood alcohol from analysis of breath. J Lab Clin Med 1950;36:306-18.
13. Norberg Å, Jones AW, Hahn RG. Pharmacokinetics of ethanol in arterial and venous blood and in end-expired breath during vasoconstriction and vasodilation. Am J Therap 1995;2:954-61.
14. Jones AW, Schuberth J. Computer-aided headspace gas chromatography applied to blood-alcohol analysis; Importance of on-line proccess control. J Forensic Sci 1989;34:1116-27.
15. Jones AW. Disappearance rate of ethanol from blood in human subjects; Implications in forensic toxicology. J Forensic Sci 1993;38:104-18.
16. Matthews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. Brit Med J 1990; 300:230-5.
17. Roland M, Tozer TN. Clinical pharmacokinetics; Concepts and applications. Lea & Febiger, Philadelphia, 2nd edition, 1989.
18. Chiou WL. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site (Part 1). Clin Pharmacokinet 1989;17:175-99.
19. Chiou WL. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site (Part II). Clin Pharmacokinet 1989;17:275-90.
20. Haggard HW, Greenberg LA, Rakieten N. Studies on the absorption, distribution, and elimination of alcohol. VI The principles governing the concentration of alcohol in the blood and the concentration causing respiratory failure. J Pharmacol Exp Therap 1940; 69:252-65.
21. Haggard HW, Greenberg LA, Lolli G. The absorption of alcohol with special reference to its influence on the concentration of alcohol appearing in the blood. J Stud Alc 1941;1:684-726.
22. Gostomzyk JG, Dilger B, Dilger K. Untersuchungen über die arteriovenöse Differenz der Alkoholkonzentration im Blut und ihre Beziehung zum Alkoholgehalt des Gehirns. Z Klin Chem Klin Biochem 1969;7:162-6.
23. Levitt MD, Furne J, DeMaster EG. Magnitude, origin, and implications of the discrepancy between blood ethanol concentrations of tail vein and arterial blood of the rat. Alcohol Clin Exp Res 1994;18:1237-41.
24. Forney RB, Hughes FW, Harger RN, Richards AB. Alcohol distribution in the vascular system; Concentrations of orally administered alcohol in blood from various points in the vascular system, and in rebreathed air, during absorption. J Stud Alc 1964;25:205-17.
25. Martin E, Moll W, Schmid P, Dettli L. The pharmacokinetics of alcohol in human breath, venous and arterial blood after oral ingestion. Eur J Clin Pharmacol 1984;26:619-26.
26. Kleemann WJ, Seibert M, Tempka A, Wolf M, Weller JP, Tröger HD. Arterielle und venöse Alkoholelimination bei 10 polytraumatisierten Patienten. Blutalkohol 1995;32:162-73.
27. Coleman TG, Manning RD, Norman RA, Guyton AC. Dynamics of water-isotope distribution. J Appl Physiol 1972;227:1371-5.
28. Chiou WL, Lam G. The significance of the arterial-venous plasma concentration differences in clearance studies. Int J Clin Pharm Ther Tox 1982;20:197-203.