Comparison of the tissue affinity of glucocorticoids to human lung, nasal and skin tissue in vitro

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 10, 2001, Pages 825-831

  Hogger P ^a  

^a Inst Pharm Lebensmittelchemie U   (Germany)

Author keywords

CAS 50 23 7; CAS 80474 14 2; Fluticasone propionate, in vitro studies, tissue affinity; Glucocorticoids; Hydrocortisone, in vitro studies, tissue affinity

Indexed keywords

FLUTICASONE PROPIONATE; GLUCOCORTICOID; HYDROCORTISONE; LIPID; PROTEIN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ADSORPTION; DRUG BINDING; DRUG EXCRETION; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; DRUG UPTAKE; HUMAN; HUMAN TISSUE; NOSE MUCOSA; PROTEIN DENATURATION; RESPIRATORY TRACT MUCOSA; SKIN;

EID: 0034778481     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300121     Document Type: Article

References (15)

1. Biphasic entry of glucocorticoids into cultured human skin keratinocytes and fibroblasts
2. Effect of age, body composition, and lipid solubility on benzodiazepine tissue distribution in rats
3. Accumulation mechanism of basic drugs in the isolated perfused rat lung
4. Binding of drugs to tissues
5. Uptake in vitro of lipophilic model compounds into adipose tissue preparations and lipids
6. Uptake of lipophilic model compounds into the isolated perfused rat epididymal adipose tissue
7. Binding of drugs to human skin: Influencing factors and the role of tissue lipids
8. Binding of prednisolone and its esters in the skin
9. Reversible fatty acid conjugation of budesonide: Novel mechanism for prolonged retention of topically applied steroid in airway tissue
10. Die bindung inhalativer glukokortikoide an menschliches lungengewebe in vitro
11. Bindung von glucocorticoiden an menschlicher haut in vitro
12. Binding of glucocorticoids to human nasal tissue in vitro
13. Distribution of inhaled fluticasone propionate between human lung tissue and serum in vivo
14. Specific age-dependence in capacity-limited uptake of propanolol by isolated rat lung
15. Time dependent effects of glucocorticoids on ACTH secretion of rat pituitaries ex vivo