IgG1, IgG4 and IgE antibody reactivity to mutant forms of the major dust mite allergen Lep d 2 among atopic and nonatopic subjects naturally exposed to Lepidoglyphus destructor

International Archives of Allergy and Immunology

Volumn 126, Issue 1, 2001, Pages 50-58

  Olsson, Susanna ^a   Van Hage Hamsten, Marianne ^a   Magnusson, Carl G M ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allergen; Atopy; Disulfide; ELISA; Farmer; Hypoallergenic variants; IgE; IgG subclass; Mutant

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G4 ANTIBODY; UNCLASSIFIED DRUG;

AGRICULTURAL WORKER; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; ATOPY; CLINICAL ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; ENVIRONMENTAL EXPOSURE; ENZYME IMMUNOASSAY; HUMAN; IMMUNE RESPONSE; MITE; MUTANT; PRIORITY JOURNAL; SENSITIZATION; URBAN POPULATION;

ALLERGENS; ANIMALS; DESENSITIZATION, IMMUNOLOGIC; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MITES; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEINS; RECOMBINANT PROTEINS;

EID: 0034775599     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000049494     Document Type: Article

References (37)

1. Increasing prevalence of asthma over 12 years among dairy farmers on Gotland: Storage mites remain dominant allergens
2. Characterisation of the mite fauna (Acari) in Swedish barn dust
3. Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals
4. Immunological changes during specific immunotherapy of grass pollen allergy: Reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T cell clones specific for Phl p 1, a major grass pollen allergen
5. The subclass nature and clinical significance of the IgG antibody response in patients undergoing allergen-specific immunotherapy
6. The role of IgG subclass antibodies in the clinical response to immunotherapy in allergic disease
7. Allergen-specific IgG4 in atopic disease
8. Genetically engineered and synthetic allergen derivatives: Candidates for vaccination against type I allergy
9. Induction of antibody responses to new B cell epitopes indicates vaccination character of allergen immunotherapy
10. Analysis of the IgE-epitope of Der f 2, a major mite allergen, by in vitro mutagenesis
11. Reduction in IgE binding to allergen variants generated by site-directed mutagenesis: Contribution of disulphide bonds to the antigenic structure of the major house dust mite allergen Der p 2
12. Recombinant allergens for immunotherapy: A Der p 2 variant with reduced IgE reactivity retains T-cell epitopes
13. IgE responsiveness to Dermatophagoides farinaein young asthmatic children: IgE binding study using recombinant allergens of Der f 1, Der f 2 and mutant proteins of Der f 2
14. Hyposensitization to allergic reaction in rDer f 2-sensitized mice by the intranasal administration of a mutant of rDer f 2, C8/119S
15. Specific immunotherapy in rDer f 2-sensitized monkeys by administration of a mutant of rDer f 2, C8/119S
16. Expression of two isoforms of Lep d 2, the major allergen of Lepidoglyphus destructor, in both prokaryotic and eukaryotic systems
17. Solution structure of Der f 2, the major mite allergen for atopic diseases
18. Contribution of disulphide bonds to antigenicity of Lep d 2, the major allergen of the dust mite Lepidoglyphus destructor
19. Evaluation of specific IgE to the recombinant group 2 mite allergens Lep d 2 and Tyr p 2 in the Pharmacia CAP system
20. Disproportional distribution of isotype specific and non-isotype specific IgG subclass anti-IgE autoantibodies in cord serum
21. Monoclonal antibodies against human IgE. Identification of a determinant restricted to IgE of the lambda light chain type
22. Monitoring allergen immunotherapy of pollen-allergic patients: The ratio of allergen-specific IgG4 and IgG1 correlates with clinical outcome
23. Prevalence of IgG anti-Der p 2 antibodies in children from high and low antigen exposure groups: Relationship of IgG and subclass antibody responses to exposure and allergic symptoms
24. Measurement of IgG subclass antibodies to the group II antigen of Dermatophagoides pteronyssinus (Der pII) in sera from children with bronchial asthma
25. Differences in titres of IgE, IgG4 and other IgG subclass anti-Der p 2 antibodies in allergic and non-allergic patients measured with recombinant allergen
26. The subclass of IgG antibody in allergic disease. II. The IgG subclass of antibodies produced following natural exposure to dust mite and grass pollen in atopic and non-atopic individuals
27. IgG1 and IgG4 antibody responses to the dust mite Lepidoglyphus destructorin a naturally exposed farming population
28. Abnormal IgG4 antibody response to aeroallergens in allergic patients
29. Differences between specificities of IgE and IgG4 antibodies: Studies using recombinant chain 1 and chain 2 of the major cat allergen Felis domesticus (Fel d) I
30. IgE and IgG4 antibodies from patients with mite allergy recognize different epitopes of Dermatophagoides pteronyssinus group II antigen (Der p 2)
31. Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation
32. Sequential switching from μ to ε via γ4 in human B cells stimulated with IL-4 and hydrocortisone
33. Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants
34. IgE binding capacity of synthetic and recombinant peptides of the major storage mite (Lepidoglyphus destructor) allergen, Lep d 2
35. Mite allergy is associated with a specific profile of IgG epitopes recognized on antigen p1 of Dermatophagoides pteronyssinus
36. Anti-betalactoglobulin IgG antibodies bind to a specific profile of epitopes when patients are allergic to cow's milk proteins
37. Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: Covert responses are unmasked by serum-free medium