Effect of dexamethasone on IL-10 and IL-12p40 production in newborns and adults

Biology of the Neonate

Volumn 80, Issue 4, 2001, Pages 262-266

  Bessler, Hanna ^a   Kagazanov, S ^b   Punsky, I ^a   Sirota, L ^c  

^a RABIN MEDICAL CENTER   (Israel)

^b Tel Aviv University ^*  (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Dexamethasone; IL 10; IL 12p40; Mononuclear cells; Newborns

Indexed keywords

DEXAMETHASONE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

ADULT; AGE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFANT; MONONUCLEAR CELL; MYCOSIS; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; SUPERNATANT; UMBILICAL CORD BLOOD;

ADULT; BIRTH WEIGHT; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FETAL BLOOD; GESTATIONAL AGE; GLUCOCORTICOIDS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INTERLEUKIN-10; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR;

EID: 0034771108     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000047154     Document Type: Article

References (34)

1. Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA
2. Lymphokine regulation of activated (G1) lymphocytes. II. Glucocorticoid and anti-Tac-induced inhibition of human T lymphocyte proliferation
3. Immunosuppression by glucocorticoids: Inhibition of production of multiple lymphokines by in vivo administration of dexamethasone
4. Glucocorticoids suppress the production of interleukin-4 by human lymphocytes
5. Analysis of the suppression of IL-1α and IL-1β production in human peripheral blood mononuclear adherent cells by a glucocorticoid hormone
6. Glucocorticoids suppress the production of tumour necrosis factor by lipopolysaccharide-stimulated human monocytes
7. Evidence that glucocorticosteroids-mediated immuno-suppressive effects do not involve altering second messenger function
8. Glucocorticoid-induced inhibition of T cell growth factor production: Effect on mitogen-induced lymphocyte proliferation
9. Effect of cyclosporin A and dexamethasone on interleukin-2 receptor gene expression
10. Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential
11. Glucocorticoids promote a Th2 cytokine response by CD4+ T cells in vitro
12. Differential sensitivity of human naive and memory CD4+ T cells for dexamethasone
13. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
14. IL-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
15. Production of natural killer cell stimulatory factor (interleukin-12) by peripheral blood mononuclear cells
16. Differential roles for IL-12 in the maintenance of immune response in infectious versus autoimmune diseases
17. Immunoregulation by interleukin-12
18. Interleukin (IL)-10 inhibits human lymphocyte interferon-gamma production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
19. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses
20. Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10
21. Increased dexamethasone sensitivity of neonatal leukocytes: Different mechanisms of glucocorticoid inhibition of T cell proliferation in adult and neonatal cells
22. Effect of dexamethasone on IL-2 and IL-3 production by mononuclear cells of newborns and adults
23. Effects of dexamethasone on IL-1β, IL-6 and TNFα production by mononuclear cells of newborns and adults
24. Differential regulation of interleukin (IL)-10 and IL-12 by glucocorticoids in vitro
25. IL-2 receptor gene expression and IL-2 production by human preterm newborns' cells
26. Interleukin-10 production by cord blood mononuclear cells
27. Regulation of interleukin-10 gene expression: Possible mechanisms accounting for its upregulation and for maturational differences in its expression by blood mononuclear cells
28. Decreased interleukin-12 levels in umbilical cord blood in children who developed acute bronchiolitis
29. Interleukin-2 and macrophage activation production by newborn lymphocytes
30. Interleukin-10 gene knock-out mice: A model of chronic inflammation
31. Interleukin-10 is a central regulator of the response to LPS in murine model of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
32. Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection
33. Interleukin-12 but not interferon-gamma production correlates with induction of T-helper type-1 phenotype in murine candidiasis
34. IL-12 is both required and prognostic in vivo for T-helper type 1 differentiation in murine candidiasis