Nitroglycerin-induced relaxation of anorectal smooth muscle: Evidence for apparent lack of tolerance development in the anaesthetized rat

British Journal of Pharmacology

Volumn 134, Issue 2, 2001, Pages 418-424

  Wang, E Q ^a   Soda, D M ^a   Fung, H L ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Anorectal smooth muscle; Cyclic GMP; Nitrate tolerance; Nitric oxide; Nitroglycerin; Relaxation

Indexed keywords

GLYCERYL TRINITRATE;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANORECTAL PRESSURE; ANUS FISSURE; ANUS SPHINCTER; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG TOLERANCE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; VASCULARIZATION;

EID: 0034770901     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704239     Document Type: Article

References (20)

1. Pharmacodynamic models of nitroglycerin-induced hemodynamic tolerance in experimental heart failure
2. Sustained antiplatelet properties of nitroglycerin during hemodynamic tolerance in rats
3. Formation of reactive oxygen species by pentaerithrityltetranitrate and glyceryl trinitrate in vitro and development of nitrate tolerance
4. Alpha-adrenoceptor responsiveness in the aged rat
5. Mechanisms of nitrate tolerance
6. Biochemical mechanism of organic nitrate action
7. Topical nitroglycerin therapy for anal fissures and ulcers
8. Treatment of benign anal disease with topical nitroglycerin
9. Possible involvement of nitroglycerin converting step in nitroglycerin tolerance
10. Mechanism of nitrate-induced vasodilation and tolerance
11. Treatment of chronic anal fissure with isosorbide dinitrate: Long-term results and dose determination
12. Alpha 2-adrenoceptor agonists and anesthesia
13. New insights into mechanisms underlying nitrate tolerance
14. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance
15. Mechanism of tolerance development to organic nitrates
16. Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: Prevention by N-acetyl-L- but not N-acetyl-D-cysteine
17. The effect of ketamine anesthesia on anorectal manometry
18. L-citrulline recycling in opossum internal anal sphincter relaxation by nonadrenergic, noncholinergic nerve stimulation
19. Nitric oxide synthase neurones and neuromuscular behaviour of the anorectum
20. Differential sensitivity among nitric oxide donors toward ODQ-mediated inhibition of vascular relaxation