In situ hybridization analysis of PrP mRNA in human CNS tissues

Neuropathology and Applied Neurobiology

Volumn 27, Issue 5, 2001, Pages 373-383

  McLennan, N F ^a,b   Rennison, K A ^b   Bell, J E ^a   Ironside, J W ^a  

^a National CJD Surveillance Unit   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Human central nervous system; In situ hybridization; Prion protein expression; Prnp gene; PrPC

Indexed keywords

MESSENGER RNA; PRION PROTEIN;

ADULT; AGED; ARTICLE; BRAIN NERVE CELL; BRAIN REGION; BRAIN TISSUE; CELL TYPE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; EPENDYMA CELL; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; NEUROPATHOLOGY; PRION DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS;

ADULT; AGED; ANIMALS; CEREBELLUM; CEREBRAL CORTEX; CREUTZFELDT-JAKOB SYNDROME; FEMALE; HIPPOCAMPUS; HUMANS; IN SITU HYBRIDIZATION; MALE; MEDULLA OBLONGATA; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; MIDDLE AGED; PRPC PROTEINS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; THALAMUS;

EID: 0034767752     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0305-1846.2001.00343.x     Document Type: Article

References (33)

1. In situ hybridization to cellular RNA with radiolabelled RNA probes
2. Differential expression of cellular prion protein on human blood and tonsil lymphocytes
3. Glycosylinositol phospholipid anchors of prion proteins
4. Astrocytic glutamate uptake and prion protein expression
5. Prion protein expression and superoxide dismutase activity
6. Mice devoid of PrP are resistant to scrapie
7. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
8. Prion protein is necessary for normal synaptic function
9. Scrapie-associated prion protein accumulates in astrocytes during scrapie infection
10. Localization of the mRNA for a chicken prion protein by in situ hybridization
11. Evidence of presynaptic location and function of the prion protein
12. Recombinant full-length murine prion protein, mPrP (23-231): Purification and spectroscopic characterization
13. Transfer of exogenous glycosylphosphatidylinositol (GPI)-linked molecules to plasma membranes
14. Extensive postmortem stability of RNA from rat and human brain
15. Analysis of prion protein mRNA by in situ hybridization in brain and placenta of sheep
16. Epithelial and endothelial expression of the green fluorescent protein reporter gene under control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice
17. T-lymphocyte activation and the cellular form of the prion protein
18. Expression of the PrP gene in the brain of sinc congenic mice and its relationship to the development of scrapie
19. The prion protein gene: A role in mouse embryogenesis?
20. PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie
21. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
22. Developmental expression of the prion protein gene in glial cells
23. Immunolocalization of the cellular prion protein in normal brain
24. Prions
25. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie
26. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labelled cRNA probes
27. Cellular prion protein is expressed in the human enteric nervous system
28. Heat shock modulates prion protein expression in human NT-2 cells
29. Scrapie prion protein contains a phosphatidylinositol glycolipid
30. C mRNA by in situ hybridization in brain, placenta, uterus and testis of rats
31. Expression of the prion protein in the rat forebrain - An immunohistochemical study
32. Molecular biology of prion propagation
33. Prion protein-deficient neurones reveal: Lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity