β-cyclodextrin inhibits the sweet taste suppressing activity of gurmarin by the formation of an inclusion complex with aromatic residues in gurmarin

Canadian Journal of Physiology and Pharmacology

Volumn 79, Issue 10, 2001, Pages 836-840

  Imoto, T ^a   Sasamoto, K ^a   Ninomiya, Y ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Cyclodextrin; Gurmarin; Gymnema sylvestre; Inclusion complex; Sweet taste

Indexed keywords

ALPHA CYCLODEXTRIN; BETA CYCLODEXTRIN; GAMMA CYCLODEXTRIN; GURMARIN; POLYPEPTIDE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL INTERACTION; DRUG MECHANISM; GEL; GEL FILTRATION CHROMATOGRAPHY; HYDROPHOBICITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SWEETNESS; TASTE; ULTRAVIOLET SPECTROSCOPY;

EID: 0034767490     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y01-064     Document Type: Article

References (9)

1. Three-dimensional structure of gurmarin, a sweet taste-suppressing peptide
2. A novel peptide isolated from the leave of Gymnema sylvestre. I. Characterization and its suppressive effect on the neural responses to sweet taste stimuli in the rat
3. Side-chain conformational changes of some amino acids and dipeptides having aromatic side-chains induced by complexation with cycloamyloses
4. Amino acid sequence of sweet taste suppressing peptide (Gurmarin) from the leaves of Gymnema sylvestre
5. Cyclodextrins and their application in analytical chemistry
6. Electrophysiological characterization of the inhibitory effect of a novel peptide gurmarin on the sweet taste response in rats
7. Gurmarin inhibition of sweet taste responses in mice
8. Lack of gurmarin sensitivity of sweet taste receptors innervated by the glossopharyngeal nerve in C57BL mice
9. Reduction of the suppressive effects of gurmarin on sweet taste responses by addition of β-cyclodextrin