Reduction of the suppressive effects of gurmarin on sweet taste responses by addition of β-cyclodextrin

Chemical Senses

Volumn 23, Issue 3, 1998, Pages 303-307

  Ninomiya, Yuzo ^a   Inoue, Masashi ^a   Imoto, Toshiaki ^b  

^a ASAHI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CYCLODEXTRIN; BETA CYCLODEXTRIN; GAMMA CYCLODEXTRIN; POLYPEPTIDE; SUCROSE; TRYPTOPHAN; TYROSINE;

ANIMAL EXPERIMENT; ARTICLE; CHORDA TYMPANI; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SWEETNESS; TASTE BUD; TASTE DISCRIMINATION;

ANIMALIA; CHORDA;

EID: 0031779029     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/23.3.303     Document Type: Article

References (9)

1. Arai, K., Ishima, R., Morikawa, S., Miyasaka, A., Imoto, T., Yoshimura, A., Aimoto, S. and Akasaka, K. (1995) Three-dimensional structure of gurmarin, a sweet suppressing peptide. J. Biomol. NMR, 5, 297-305.
2. Imoto, T. and Ninomiya, Y. (1997) Nature of the active site of gurmarin as deduced from interaction with β-cyclodextrin (in Japanese). Jpn. J. Taste Smell Res., in press.
3. Imoto, T., Miyasaka, A., Ishima, R. and Akasaka, K. (1991) A novel peptide isolated from the leaves of Gymnema sylvestre. I. Characterization and its suppressive effect on the neural responses to sweet taste stimuli in the rat. Comp. Biochem. Physiol., 100A, 309-314.
4. Inoue, Y. and Miyata, Y. (1981) Formation and molecular dynamics of cycloamylose inclusion complexes with phenylalanine. Bull. Chem. Soc. Jpn., 54, 809-816.
5. Inoue, Y., Okuda, T. and Miyata, Y. (1981) Side-chain conformational changes of some amino acids and dipeptides having aromatic side chains induced by complexation with cycloamyloses. J. Am. Chem. Soc., 103, 7379-7394.
6. Li, S. and Purdy, W.C. (1992) Cyclodextrins and their applications in analytical chemistry. Chem. Rev., 92, 1457-1470.
7. Miyasaka, A. and Imoto, T. (1995) Electrophysiological characterization of the inhibitory effect of a novel peptide gurmarin on the sweet taste response in rats. Brain Res., 676, 63-68.
8. Ninomiya, Y. and Imoto, T. (1995) Gurmarin inhibition of sweet taste responses in mice. Am. J. Physiol., 268, R1029-R1025.
9. Ninomiya, Y., Inoue, M., Imoto, T. and Nakashima, K. (1997) Lack of gurmarin sensitivity of sweet taste receptors innervated by the glossopharyngeal nerve in C57BL mice. Am. J. Physiol., 272, R1002-R1006.