BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 25, Issue 8, 2001, Pages 1641-1659

  Wie, Myung Bok ^a   Koh, Jae Young ^b   Won, Moo Ho ^c   Lee, Jae Chul ^c   Shin, Tae Kyun ^a   Moon, Chang Jong ^a   Ha, Hyun Joo ^a   Park, Shin Mi ^a   Kim, Hyoung Chun ^d  

^a Jeju National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Hallym University   (South Korea)

^d Kangwon National University   (South Korea)

Author keywords

Apoptosis; BAPTA AM; Cycloheximide; Free radical; Intracellular calcium chelator; Lipoxygenase; Necrosis; Neuronal cultures; TUNEL; tocopherol

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; 6,7 DINITRO 2,3 QUINOXALINEDIONE; ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; CALCIUM CHELATING AGENT; CASPASE INHIBITOR; CATALASE; CYCLOHEXIMIDE; DACTINOMYCIN; DEFEROXAMINE; DIZOCILPINE; ESCULETIN; FREE RADICAL; LIPOXYGENASE; N(G) NITROARGININE METHYL ESTER; NERVE GROWTH FACTOR; NITRIC OXIDE SYNTHASE; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATTENUATION; CELL SUBPOPULATION; CONTROLLED STUDY; EDEMA; ENDOPLASMIC RETICULUM; EXPOSURE; GLIA CELL; INHIBITION KINETICS; MEMBRANE RUPTURE; MITOCHONDRION; MOUSE; NERVE CELL CULTURE; NERVE CELL MEMBRANE; NERVE CELL NECROSIS; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION;

ANIMALS; CALCIUM; CELL DEATH; CEREBRAL CORTEX; CHELATING AGENTS; CULTURE TECHNIQUES; EGTAZIC ACID; FREE RADICALS; HOMEOSTASIS; LIPOXYGENASE; MICE; MICE, INBRED ICR; NECROSIS;

EID: 0034762086     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(01)00202-0     Document Type: Article

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