Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitor

Chemical and Pharmaceutical Bulletin

Volumn 49, Issue 10, 2001, Pages 1237-1244

  Nishida, H ^a   Miyazaki, Y ^a   Kitamura, Y ^a   Ohashi, M ^a   Matsusue, T ^a   Okamoto, A ^a   Hosaka, Y ^a   Ohnishi, S ^a   Mochizuki, H ^a  

^a MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

4 (piperidino)pyridine; Factor Xa inhibitor; M55113; Structure activity relationship

Indexed keywords

1 SULFONYL 3 PIPERAZINONE DERIVATIVE; 2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; 4 [(6 CHLORO 2 NAPHTHALENYL)SULFONYL] 1 [[1 (4 PYRIDINYL) 4 PIPERIDINYL]METHYL]PIPERAZINONE; [N [4 [(1 ACETIMIDOYL 4 PIPERIDYL)OXY]PHENYL] N [(7 AMIDINO 2 NAPHTHYL)METHYL]SULFAMOYL]ACETIC ACID; BLOOD CLOTTING FACTOR 10A INHIBITOR; ENZYME PRECURSOR; M 55113; PROTHROMBIN; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING; CARDIOVASCULAR DISEASE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN DEGRADATION;

ANTICOAGULANTS; CRYSTALLOGRAPHY, X-RAY; FACTOR XA; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRYPSIN INHIBITORS;

EID: 0034761462     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.49.1237     Document Type: Article

References (28)