Photodecarboxylation of DX-9065a, a new factor Xa inhibitor, in aqueous solution

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 1, 1998, Pages 131-135

  Kawai, Yukinori ^a   Matsubayashi, Kyuichi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

DX 9065a; Kinetics; Photodecarboxylation; Photodegradation

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; BLOOD CLOTTING FACTOR 10A INHIBITOR; BUFFER; DRUG METABOLITE;

AQUEOUS SOLUTION; ARTICLE; DECARBOXYLATION; DISSOCIATION CONSTANT; DRUG STABILITY; IRRADIATION; PH; PHOTODEGRADATION; PKA; SUNLIGHT;

EID: 0031909080     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.131     Document Type: Article

References (12)

1. a) Chen T. M., Chafetz L., J. Pharm. Sci., 76, 703-706 (1987);
2. b) Lee Y. J., Padula J., Lee H., ibid., 77, 81-86 (1988).
3. Mizuno T., Hanamori M., Akimoto K., Nakagawa H., Arakawa K., Chem. Pharm. Bull., 42, 160-162 (1994).
4. Morimura T., Ohno T., Matsukura H., Nobuhara Y., Chem. Pharm. Bull., 43, 1000-1004 (1995).
5. Majeed I. A., Murray W. J., Newton D. W., Othman S., Al-turk W. A., J. Pharm. Pharmacol., 39, 1044-1046 (1987).
6. Torniainen K., Tammilehto S., Ulvi U., Int. J. Pharm., 132, 53-61 (1996).
7. Ono M., Kitaoka H., Hakusui H., Abstracts of Papers, The 115th Annual Meeting of the Pharmaceutical Society of Japan, Sendai, March 1995, Part 4, p. 50.
8. Isobe K., Mohri K., Taga J., Sasaki Y., Tsuda Y., Chem. Pharm. Bull., 40, 2188-2190 (1992).
9. Margerum J. D., J. Am. Chem. Soc., 87, 3772-3773 (1965).
10. Joschek H. I., Grossweiner L. I., J. Am. Chem. Soc., 88, 3261-3268 (1966).
11. Harbour J. R., Chow V., Bolton J. R., Can. J. Chem., 52, 3549-3553 (1974).
12. Martell A. E., Motekaitis R. J., "Determination and Use of Stability Constants," VCH Publishers Inc., New York, 1992.