Unraveling the molecular make-up of the glomerular podocyte slit diaphragm

Experimental Nephrology

Volumn 9, Issue 6, 2001, Pages 355-359

  Khoshnoodi, Jamshid ^a   Tryggvason, Karl ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Department of Medical Biochemistry and Biophysics   (Sweden)

Author keywords

CD2AP; Congenital nephrotic syndrome; Nephrin; P cadherin; Podocyte; Slit diaphragm; ZO 1

Indexed keywords

CD2 ASSOCIATED PROTEIN; NEPHRIN; PROTEIN; UNCLASSIFIED DRUG;

GENE MUTATION; GLOMERULUS FILTRATION; HUMAN; MOLECULAR BIOLOGY; MOLECULAR GENETICS; PODOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEINURIA; SHORT SURVEY; ULTRASTRUCTURE;

EID: 0034756046     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: 10.1159/000052632     Document Type: Short Survey

References (32)

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4. 125I-bovine serum albumin
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7. Porous substructure of the glomerular slit diaphragm in the rat and mouse
8. The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium
9. The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1
10. Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody
11. Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes
12. Positionally cloned gene for a novel glomerular protein - Nephrin - Is mutated in congenital nephrotic syndrome
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15. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinurea and neonatal death
16. Nephrin is specifically located at the slit diaphragm of glomerular podocytes
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18. CEA adhesion molecules: Multifunctional proteins with signal-regulatory properties
19. Regulation of axonal growth in the vertebrate nervous system by interactions between glycoproteins belonging to two subgroups of the immunoglobulin superfamily
20. Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney
21. Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin
22. The glomerular slit diaphragm is a modified adherens junction
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26. Precocious mammary gland development in P-cadherin-deficient mice
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29. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
30. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis
31. Structure of the gene for congenital nephrotic syndrome of the Finnish type (NPHS1) and characterization of mutations
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