Gene expression during fracture healing in normal mouse: In situ hybridization on hard tissues for investigation of regenerative mechanisms

Acta Histochemica et Cytochemica

Volumn 34, Issue 5, 2001, Pages 321-328

  Kitazawa, R ^a   Kitazawa, S ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bone matrix proteins; Bone morphogenetic protein (BMP); Fracture healing; In situ hybridization; RANKL

Indexed keywords

ANIMAL MODEL; BINDING SITE; CARTILAGE CELL; CELL DIFFERENTIATION; DAY LENGTH; DNA PROBE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IN SITU HYBRIDIZATION; MESENCHYME; MOUSE; OSTEOBLAST; POLYMERASE CHAIN REACTION; REGENERATIVE ABILITY; SIGNAL TRANSDUCTION; SINGLE STRANDED DNA; WOUND HEALING;

ANIMALIA; MAMMALIA;

EID: 0034753911     PISSN: 00445991     EISSN: None     Source Type: Journal    
DOI: 10.1267/ahc.34.321     Document Type: Article

References (44)

1. Expression of human bone morphogenetic protein-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages
2. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
3. Runt homology domain proteins in osteoblast differentiation: AML3/Cbfa1 is a major component of a bone-specific complex
4. Evidence from normal expression and targeted misexpression that bone morphogenetic protein-4 (Bmp-4) plays a role in mouse embryonic lung morphogenesis
5. Immunolocalization and expression of bone morphogenetic protein 2 and 4 in fracture healing
6. Identification of transforming growth factor β family members present in bone-inductive protein purified form bovine bone
7. Bone Morphogenetic Protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts
8. A common plan for dorsoventral patterning in Bilateria
9. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
10. Bone morphogenetic protein-3/osteogenin antagonizes BMP2-induced osteogenic differentiation and is a negative regulator of bone formation
11. Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
12. Expression of platelet-derived growth factor a and b mRNAs during fracture healing in the normal mouse
13. BMP-3 mRNA expression during endochondral ossification of mouse bone tissue
14. BMP-6 commits chondrocytes to the hypertrophic phenotype
15. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
16. Maturational disturbance of chondrocytes in Cbfa1-deficient mice
17. A RUNX2/PEBP2αA/Cbfa1 mutation in cleidocranial dysplasia revealing the link between the gene and Smad
18. Modulation of osteonectin and osteopontin expression during fracture healing of mouse bone tissue
19. Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene
20. Expression of bone morphogenetic protein (BMPs) in fractured mouse bone tissue: In situ hybridization with polymerase chain reaction (PCR)-derived antisense DNA probe
21. In situ hybridization using polymerase chain reaction (PCR)-derived single-stranded DNA probe and S1 nuclease
22. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
23. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
24. Transient upregulation of Cbfa1 in response to bone morphogenetic protein-2 and transforming growth factor b1 in C2C12 myogenic cells coincides with suppression of myogenic phenotype but in not sufficient for osteoblast differentiation
25. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP 2)
26. The biology of fracture healing in long bones
27. RANK is the essential signaling receptor for osteoclast differentiation in osteoclastogenesis
28. Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing
29. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
30. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
31. Transcriptional regulation of osteopontin gene in vivo by PEBP2aA/CBFA1 and ETS1 in the skeletal tissues
32. Assessment of decalcifying protocols for detection of specific RNA by non-radioactive in situ hybridization
33. Expression of BMP-2 and TGF-beta 1 mRNA during healing of the rabbit mandible
34. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
35. Purification and characterization of a bone-inducing protein from a murine osteosarcoma (Dunn type)
36. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells
37. Bone: Formation by auto induction
38. Recombinant human bone morphogenetic protein induces bone formation
39. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
40. Novel regulators of bone formation: Molecular clones and activities
41. Transcriptional regulation of the BMP-2 gene in murine chondroblasts
42. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
43. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
44. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL