Acute and subacute toxicity and efficacy of S-nitrosylated captopril, an ACE inhibitor possessing nitric oxide activities

Food and Chemical Toxicology

Volumn 39, Issue 12, 2001, Pages 1135-1143

  Jia, L ^a,c   Pei, R ^b   Lin, M ^b   Yang, X ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b East Hospital   (China)

^c CTRC Institute for Drug Development   (United States)

Author keywords

Acute toxicity; Captopril; Efficacy; LD50; Nitric oxide; S nitrosocaptopril; S nitrosoglutathione; Subacute toxicity

Indexed keywords

CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; S NITROSOCAPTOPRIL;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FOOD INTAKE; GROWTH RATE; HEMATOLOGY; HYPERTENSION; HYPOTENSION; LD 50; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; RAT; RODENT;

ACUTE TOXICITY TESTS; ADMINISTRATION, ORAL; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BLOOD PRESSURE; CAPTOPRIL; CAUSE OF DEATH; DRUG EVALUATION, PRECLINICAL; ENERGY INTAKE; FEMALE; GROWTH; HYPERTENSION; HYPOTENSION; INJECTIONS, INTRAVENOUS; LETHAL DOSE 50; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE DONORS; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS; TREATMENT OUTCOME; VASODILATOR AGENTS;

RODENTIA;

EID: 0034753837     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(01)00079-5     Document Type: Article

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