Maturation of xenoantibody gene expression during the humoral immune response of rats to hamster xenografts

Xenotransplantation

Volumn 8, Issue 4, 2001, Pages 291-302

  Wu, Gordon D ^a   Gochi, Eiji ^a   Jin, Yang Sun ^a   Swensson, Joyce ^a   Starnes, Vaughn A ^a   Cramer, Donald V ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Hamster; Heart antibody response; Immunoglobulin gene; Rat; Xenotransplantation

Indexed keywords

ANTIBODY; COMPLEMENTARY DNA; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M ANTIBODY; IMMUNOGLOBULIN SUBCLASS;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GRAFT REJECTION; HAMSTER; HEART TRANSPLANTATION; HUMORAL IMMUNITY; IMMUNOSTIMULATION; MALE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; RAT; RAT STRAIN; SOMATIC MUTATION; XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, HETEROPHILE; B-LYMPHOCYTES; CRICETINAE; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; MALE; MESOCRICETUS; MOLECULAR SEQUENCE DATA; MYOCARDIUM; RATS; RATS, INBRED LEW; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TRANSPLANTATION, HETEROLOGOUS;

EID: 0034752621     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.2001.00136.x     Document Type: Article

References (42)

1. Xenogeneic transplantation: A review
2. Revisiting a challenge in transplantation: Discordant xenografting
3. The humoral response to xenografts
4. Xenogeneic transplantation
5. Transplantation of discordant xenografts: A review of progress
6. The use of a pig liver xenograft for temporary support of a patient with fulminant hepatic failure
7. Baboon-to-human liver transplantation. Reply
8. Genetic control of the humoral immune response to xenografts. I. Functional characterization of rat mono-clonal antibodies to hamster heart xenografts
9. Accommodation of vascularized xenografts: Expression of'protective genes' by donor endothelial cells in a host Th2 cytokine environment
10. Xenotransplantation in rodents: A review and reclassification
11. Prolonged survival of hamster-to-rat liver xenografts using splenectomy and cyclosporine administration
12. The prolongation of concordant hamster-to-rat cardiac xenografts by brequinar sodium
13. A crucial effect of splenectomy on prolonging cardiac xenograft survival in combination with cyclosporine
14. Evidence that long-term survival of concordant xenografts is achieved by inhibition of antispecies antibody production
15. Role of antibody synthesis and complement activation in concordant xenograft retransplantation
16. Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection
17. Suppression of T-independent IgM xenoantibody formation by lefluno-mide during xenografting of hamster hearts in rats
18. Genetic control of the humoral immune response to xenografts. II. Mono-clonal antibodies that cause rejection of heart grafts are encoded by germline immunoglobulin genes
19. H genes responsible for encoding rat immunoglobin G xenoantibodies to hamster heart grafts
20. Maintenance and reversibility of natural killer cell- and T cell-independent B lymphocyte xenotolerance in athymic nude rats
21. Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment
22. Natural antibodies against bone marrow cells of a concordant xenogeneic species
23. A physicochemical study of protein G, a molecule with unique immunoglobulin G-binding properties
24. Purification and some properties of streptococcal protein G, a novel IgG-binding reagent
25. Structure of the IgG-binding regions of streptococcal protein
26. H segments
27. H gene structure with antibodies to common infectious agents
28. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse
29. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
30. Accommodation and T-independent B cell tolerance in rats with long term surviving hamster heart xenografts
31. Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplantated with hamster hearts
32. Blockade of induced xenoantigen expression prevents rejection after retransplantation of accommodated hamster-to-rat heart xenografts
33. Modulation of host xenoantibody responses with donor specific transfusion correlated with prolonged xenograft survival
34. Synergistic mechanisms by which sirolimus and cyclosporin inhibit rat heart and kidney allograft rejection
35. Delayed xenograft rejection in the concordant hamster heart into lewis rat model
36. The role of BSAP in immunoglobulin isotype switching and B-cell proliferation
37. Immunoglobulins: Molecular genetics
38. Xenoantibody response of patients with severe acute liver failure exposed to porcine antigens following treatment with a bioartificial liver
39. Accommodated xenografts survive in the presence of anti-donor antibodies and complement that precipitate rejection of naive xenografts
40. H germline progenitors
41. T cell-independent antigens type 2