Hereditary breast/ovarian cancer - Pitfalls in genetic counseling

Clinical Genetics

Volumn 60, Issue 4, 2001, Pages 310-313

  Dagan, E ^a,b   Gershoni Baruch, R ^a,c  

^a RAMBAM MEDICAL CENTER   (Israel)

^b UNIVERSITY OF HAIFA   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Genetic counseling; Hereditary breast cancer; Ovarian cancer

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; FAMILIAL CANCER; FAMILY; FAMILY HISTORY; FEMALE; GENE MUTATION; GENE SEGREGATION; GENETIC COUNSELING; GENETIC PROCEDURES; GENETIC RISK; GENOTYPE; HUMAN; JEW; MAJOR CLINICAL STUDY; MOLECULAR GENETICS; OVARY CANCER; PEDIGREE ANALYSIS; PRIORITY JOURNAL; RISK ASSESSMENT;

ADULT; AGED; BREAST NEOPLASMS; FEMALE; FOUNDER EFFECT; GENES, BRCA1; GENES, BRCA2; GENETIC COUNSELING; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; JEWS; MALE; MIDDLE AGED; OVARIAN NEOPLASMS; PEDIGREE; POINT MUTATION;

EID: 0034750843     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0004.2001.600410.x     Document Type: Article

References (23)

1. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
2. Identification of the breast cancer susceptibility gene BRCA2
3. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually
4. Autosomal dominant inheritance of early onset breast cancer
5. Genetic analysis of breast cancer in the cancer and steroid hormone study
6. The incidence of breast cancer: The global burden, public health considerations
7. Breast and ovarian cancer incidence in BRCA1 mutation carriers
8. Germline mutation of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation
9. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer
10. The risk of cancer associated with specific mutations in BRCA1 and BRCA2 among Ashkenazi Jews
11. The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals
12. The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%
13. Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2
14. Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families
15. The founder mutation 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women
16. Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: Frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families
17. Co-segregation of BRCA1 185delAG mutation and BRCA2 6174delT mutation in one single family
18. Double heterozygotes for the Ashkenazi founder mutations in BRCA1 and BRCA2 genes
19. A breast/ ovarian cancer patient with germline mutations in both BRCA1 and BRCA2
20. A family with three germline mutations in BRCA1 and BRCA2
21. The Jewish Ashkenazi founder mutations in the BRCA1/BRCA2 genes are not found at an increased frequency in Ashkenazi patients with prostate cancer
22. Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cancer in Jewish men
23. No evidence for a role of BRCA1 or BRCA2 mutations in Ashkenazi Jewish families with hereditary prostate cancer