Stabilizing and solubilizing effects of sulfobutyl ether β-cyclodextrin on prostaglandin E1 analogue

Pharmaceutical Research

Volumn 18, Issue 11, 2001, Pages 1578-1585

  Uekama, K ^a   Hieda, Y ^a   Hirayama, F ^a   Arima, H ^a   Sudoh, M ^b   Yagi, A ^b   Terashima, H ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Inclusion complex; Prostaglandin E1 analogue; Solubilization; Stabilization; Sulfobutyl ether cyclodextrin

Indexed keywords

7 [3 HYDROXY 2 [3 HYDROXY 4 (3 METHOXYMETHYLPHENYL) 1 BUTENYL] 5 OXOCYCLOPENTYL] 5 THIAHEPTANOIC ACID METHYL ESTER; BETA CYCLODEXTRIN SULFOBUTYL ETHER; CYCLODEXTRIN; PROSTAGLANDIN E1 DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; CATALYSIS; DEHYDRATION; DRUG DEGRADATION; DRUG SOLUBILITY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ALPROSTADIL; BETA-CYCLODEXTRINS; CIRCULAR DICHROISM; CYCLODEXTRINS; DRUG STABILITY; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0034749741     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013034615464     Document Type: Article

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