Influence of a Cα-substitution on the S-pivaloyl-2-thioethyl chain on the anti-HIV activity and stability of the resulting zidovudine mononucleoside phosphotriester

Antiviral Chemistry and Chemotherapy

Volumn 12, Issue 4, 2001, Pages 223-232

  Peyrottes, S ^a   Perigaud C ^a   Aubertin, A M ^a   Gosselin, G ^a   Imbach, J L ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

AZT; HIV; Mononucleotide; Phosphotriester; Prodrug

Indexed keywords

3' AZIDO 2',3' DIDEOXYTHYMIDIN 5' YL BIS(S PIVALOYL 2 THIOISOPROPYL)PHOSPHATE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; METHYL GROUP; NUCLEOTIDE; PHOSPHATE; S PIVALOYL 2 THIOETHYL DERIVATIVE; S PIVALOYL 2 THIOISOPROPYL DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE 5' TRIPHOSPHATE; ZIDOVUDINE DERIVATIVE; DRUG DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS; CHEMISTRY; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

DRUG STABILITY; REVERSE TRANSCRIPTASE INHIBITORS; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; ZIDOVUDINE;

EID: 0034747196     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020101200403     Document Type: Article

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