Evidence supporting the activity of 2'-C-cyano-2'-deoxy-1-β-D-arabino- pentafuranosylcytosine as a terminatorin enzymatic DNA-chain elongation

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 18, 1998, Pages 2559-2562

  Hayakawa, Yoshihiro ^a   Kawai, Rie ^a   Otsuki, Kaori ^a   Kataoka, Masanori ^a   Matsuda, Akira ^b  

^a NAGOYA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2' C CYANO 2' DEOXY 1 BETA DEXTRO ARABINOFURANOSYLCYTOSINE; 2' C CYANO 2' DEOXY 1 BETA DEXTRO ARABINOPENTAFURANOSYLCYTOSINE 3' PHOSPHORIC ACID; CYTARABINE DERIVATIVE; CYTOSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DNA CLEAVAGE; DRUG MECHANISM; DRUG STABILITY; DRUG SYNTHESIS; LEUKEMIA CELL; MOUSE; NONHUMAN;

ANTINEOPLASTIC AGENTS; CYTARABINE; DNA; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; NUCLEIC ACID CONFORMATION;

EID: 0032558531     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00459-4     Document Type: Article

References (14)

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12. (7) Deallylation with a catalytic amount of the Pd(0) complex in the presence of a nucleophile such as diethylammonium hydrogencarbonate resulted in the failure. In this case, the undesired β-elimination of the internucleotide linkage took place to give a mixture of 8 and allyl thymidine 5′-phosphate (10).
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14. (9) The product 8 also decomposed under the basic conditions to produce several compounds.