Efficacy of 3′-azido 3′deoxythymidine (AZT) in preventing HTLV-1 transmission to human cord blood mononuclear cells

Virus Research

Volumn 78, Issue 1-2, 2001, Pages 67-78

  Zhang, Jing ^a   Balestrieri, Emanuela ^a,c   Grelli, Sandro ^a   Matteucci, Claudia ^a   Pagnini, Veronica ^a   D'Agostini, Cartesio ^a   Mastino, Antonio ^b   Macchi, Beatrice ^a,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Antiretroviral therapy; Apoptosis; AZT; Cord blood mononuclear cells; HTLV 1

Indexed keywords

TAX PROTEIN; VIRUS DNA; VIRUS RNA; ZIDOVUDINE; INTERLEUKIN 2;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL LINE; COCULTURE; DOSE RESPONSE; DRUG EFFECT; FETUS BLOOD; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; ISOLATION AND PURIFICATION; MONONUCLEAR CELL; PHYSIOLOGY; PROVIRUS; VIROLOGY; VIRUS REPLICATION; WESTERN BLOTTING; ANTIVIRAL ACTIVITY; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS INFECTION; IC 50; MONITORING; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL CORD BLOOD; VIRUS GENE; VIRUS TRANSMISSION;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; COCULTURE TECHNIQUES; DNA, VIRAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FETAL BLOOD; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKOCYTES, MONONUCLEAR; PROVIRUSES; RNA, VIRAL; VIRUS REPLICATION; ZIDOVUDINE;

HTLV; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 0034742157     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(01)00285-4     Document Type: Article

References (36)

1. Intrathecal synthesis of IgG antibodies to HTLV-I supports an etiological role for HTLV-I in tropical spastic paraparesis
2. The toxicity of azidothymidine on human and animal cells in culture at concentrations used for antiviral therapy
3. Reduction of maternal-infant transmission of human immunodeficiency virus type I with zidovudine treatment
4. Regulation of lymphocyte survival by the BCL-2 gene family
5. HTLV-I/II seroprevalence in the Gambia: A study of mother-child pairs
6. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophages-astroglia interactions: Implications for the neuropathogenesis of HIV disease
7. Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine
8. Brief report: Treatment of adult T-cell leukemia-lymphoma with zidovudine and interferon alfa
9. Mother to child transmission of human T-cell leukemia virus type I
10. Intrauterine transmission of human T-cell leukemia virus type 1 in rats
11. Clinical study on the effect of natural alfa-interferon (HLBI) in the treatment of adult T-cell leukemia
12. Antiviral effect of zidovudine in the experimental model of adult T cell leukemia in rabbits
13. HTLV-1 proviral DNA in umbilical cord blood of babies born to carrier mothers
14. Temporal regulation of viral and cellular gene expression during human T-lymphotropic virus type-I mediated lymphocyte immortalization
15. Detection of mRNA for the tax 1/rex 1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction
16. Protective effect of interferon beta on human T cell leukemia virus type I infection of CD4+ T cells isolated from human cord blood
17. AZT inhibits the transmission of human T cell leukaemia/lymphoma virus type I to adult peripheral blood mononuclear cells in vitro
18. A prospective study of transmission by transfusion of HTLV-I and risk factors associated with seroconversion
19. Human T-lymphotropic virus type I infection
20. Pharmacological inhibition of in vitro infectivity of human T-lymphotropic virus type I
21. Identification of nuclei from apoptotic necrotic and viable lymphoid cells by using multiparameter flow cytometry
22. Detection of type C retrovirus particles on a cord blood T-cell line derived by cocultivation of normal human lymphocytes and human leukemic T-cells
23. Chronic inflammatory arthropathy associated with HTLV-I
24. Incorporation of zidovudine into leucocyte DNA from HIV-I positive adults and pregnant women and cord blood from infants exposed in utero
25. HTLV-I associated myelopathy, a new clinical entity
26. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
27. Immunopathological mechanisms of human T-cell lymphotropic virus type I (HTLV-I) uveitis. Detection of HTLV-I infected cells in the eye and their constitutive cytokine production
28. Identification of HTLV-I sequence in cord blood mononuclear cells of neonates born to HTLV-I antigen/antibody-positive mothers by polymerase chain reaction
29. Detection of HTLV-1 antigen in peripheral and cord blood lymphocytes from carrier mothers
30. Heterosexual transmission of human T cell leukemia/lymphoma virus type I among married couples in southwestern Japan: An initial report from the Miyazaki cohort study
31. Genotoxicity of 3′-azido-3′deoxythymidine in the human lymphoblastoid cell line, TK6: Relationship between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT
32. Effect of lamivudine on human T-cell leukemia virus type I (HTLV-I) DNA copy number, T-cell phenotype, and anti-Tax cytotoxic T-cell frequency in patients with HTLV-1 associated myelopathy
33. Mother-to-child transmission of human T-cell leukemia/lymphoma virus type I: Implication of high antiviral antibody titer and high proviral load in carrier mothers
34. Mother-to-child transmission of human T-lymphotropic virus type II
35. Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding
36. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease