1α, 25-Dihydroxyvitamin D3 inhibits hepatic chromosomal aberrations, DNA strand breaks and specific DNA adducts during rat hepatocarcinogenesis

Cellular and Molecular Life Sciences

Volumn 58, Issue 8, 2001, Pages 1141-1149

  Saha, B K ^a   Bishayee, A ^a,b   Kanjilal, N B ^a   Chatterjee, M ^a  

^a JADAVPUR UNIVERSITY   (India)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

2 Acetylaminofluorene; Chromosomal aberration; DNA adduct; DNA strand break; Rat liver; Streptozotocin; Vitamin D3

Indexed keywords

CALCITRIOL; DEOXYGUANOSINE; N (DEOXYGUANOSIN 8 YL) 2 FLUORENYLAMINE; PROPYLENE GLYCOL; STREPTOZOCIN; UNCLASSIFIED DRUG; 2 METHYL 1,25 DIHYDROXYVITAMIN D3; 2-METHYL-1,25-DIHYDROXYVITAMIN D3; ANTIOXIDANT; CARCINOGEN; DRUG DERIVATIVE; N (2 FLUORENYL)ACETAMIDE; VITAMIN D;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER PREVENTION; CHROMOSOME ABERRATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA ADDUCT; DNA STRAND BREAKAGE; LIVER CANCER; LIVER CARCINOGENESIS; METAPHASE; NONHUMAN; RAT; ANIMAL; CARCINOGEN TESTING; CYTOLOGY; DNA DAMAGE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GENETICS; LIVER; LIVER CELL; MALE; SPRAGUE DAWLEY RAT;

2-ACETYLAMINOFLUORENE; ANIMALS; ANTIOXIDANTS; CARCINOGENICITY TESTS; CARCINOGENS; CHROMOSOME ABERRATIONS; DIABETES MELLITUS, EXPERIMENTAL; DNA ADDUCTS; DNA DAMAGE; HEPATOCYTES; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN; VITAMIN D;

EID: 0034741969     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000928     Document Type: Article

References (59)

1. Prospects for the use of antioxidant therapies
2. 3 receptors in established human cancer cell lines in culture
3. 3 analogue shows relation to promoter selectivity
4. 3
5. 3-resistant MCF-7 cell line
6. Toward therapeutic intervention of cancer by vitamin D compounds
7. 3
8. 3 in chemically induced rat colon carcinogenesis
9. 3-treated HL 60 cells
10. Recombinant human GM-CSF enhances the anti-proliferative activity of vitamin D in MCF-7 human breast cancer clonogenic cells
11. 3 in the human prostate carcinoma cell line
12. Site-specific DNA methylation and apoptosis: Induction by diabetogenic streptozotocin
13. Stimulation of tumor growth in adult rats in vivo during acute streptozotocin-induced diabetes
14. Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer
15. Diabetes mellitus and the risk of primary liver cancer
16. Risk of endometrial and breast cancer in patients with diabetes mellitus
17. Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer
18. Diabetes and endometrial cancer: An Italian case-control study
19. Cancer incidence in a population-base cohort of patients hospitalized with diabetes mellitus in Denmark
20. Latent expression of p53 mutations and radiation-induced mammary cancer
21. Genomic instability induced by ionizing radiation
22. Chromosome aberration and cancer
23. Fluorimetric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiations
24. DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability
25. 3
26. Mechanistic basis for nonlinearities and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine
27. 3 in murine lymphoma
28. 3 suppresses the effect of streptozotocin-induced diabetes during chemical rat liver carcinogenesis
29. 1
30. Sensitive induction of chromosome aberration in the in vivo liver cells of rats by N-nitrosodiethylamine
31. β-Carotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine
32. Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo
33. Native and denatured DNA crosslinked and palindromic DNA analyzed by a sensitive fluorimetric procedure
34. Estimation of single-strand breaks induced in the dried film of DNA by high energy alpha particle from a cyclotron
35. 32P-postlabeling analysis of aromatic carcinogen: DNA adducts
36. 32P-postlabeling analysis of nonradioactive aromatic carcinogen-DNA adducts
37. Distribution of initial and persistent 2-acetylaminofluorene-induced DNA adducts within DNA loops
38. Cellular oncogenes and multistep carcinogenesis
39. Immunoglobin gene rearrangements as unique clonal markers in human lymphoid neoplasms
40. Genetic instability, suppression and human cancer
41. Mechanisms of tumor progression
42. Preneoplastic rat liver cells in vitro: Slow progression without promoters, hormones or growth factors
43. Chromosomal analysis of a diethylnitrosamine-induced tumorigenic and a nontumorigenic rat liver cell
44. Vanadium-mediated suppression of diethylnitrosamine-induced chromosomal aberrations in rat hepatocytes and its correlation with induction of hepatic glutathione and glutathione S-transferase
45. Diethylnitrosamine-induced chromosomal changes in rat liver cells
46. Non-random distribution of mutagen-induced chromosome breaks in lymphocytes of patients with different malignancies
47. Correlation of morphological transformation to sister-chromatid exchanges induced by split doses of chemical and physical carcinogens on cultured Syrian hamster cells
48. Human diseases associated with defective DNA repair
49. 2 on the frequencies of chromosomal aberrations induced by thiotepa in root tips of Vicia fava
50. 3 on human T lymphocyte activation and proliferation: A cell cycle analysis
51. 3 leads to the induced differentiation of the myelomonocytic cell line U937
52. Kip1 accumulation during the cell cycle
53. 3 in HL60 cells
54. Formation and removal of DNA adducts in rat liver treated with N-hydroxyderivatives of 2-acetylaminofluorene, 4-acetylaminobiphenyl and 2-acetylaminophenanthrene
55. DNA adduct formation and removal during chronic administration of a carcinogenic aromatic amine
56. Analysis of DNA adducts in putative premalignant hepatic nodules and nontarget tissues of rats during 2-acetylaminofluorene carcinogenesis
57. Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene
58. Association between DNA strand breaks and specific DNA adducts in murine hepatocytes following in vivo and in vitro exposure to N-hydroxy-2-acetylaminofluorene and N-acetoxy-2-acetylaminofluorene