Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes

British Journal of Clinical Pharmacology

Volumn 52, Issue 1, 2001, Pages 100-103

  Senda, C ^a,b   Yamaura, Y ^b   Kobayashi, K ^b   Fujii, H ^c   Minami, H ^c   Sasaki, Y ^c   Igarashi, T ^a   Chiba, Kan ^b  

^a NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

CYP2D6*10; Human liver microsomes; Mexiletine

Indexed keywords

4 HYDROXYMEXILETINE; ANTIARRHYTHMIC AGENT; CYTOCHROME P450 2D6; HYDROXYMETHYLMEXILETINE; MEXILETINE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; GENOTYPE; HETEROZYGOTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOZYGOTE; HUMAN; HUMAN TISSUE; LIVER MICROSOME; PRIORITY JOURNAL; STRAIN DIFFERENCE; GENETICS; HYDROXYLATION; METABOLISM; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ALLELES; ANTI-ARRHYTHMIA AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; HETEROZYGOTE; HOMOZYGOTE; HUMANS; HYDROXYLATION; MEXILETINE; MICROSOMES, LIVER; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 0034741353     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2001.01411.x     Document Type: Article

References (10)

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3. Influence of debrisoquine phenotype and of quinidine on mexiletine disposition in man
4. Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
5. Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes
6. Propranolol disposition in Chinese subjects of different CYP2D6 genotypes
7. Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers
8. MP) activity in human liver samples obtained as surgical waste from Japanese patients
9. Oxidative metabolism of omeprazole in human liver microsomes: Cosegregation with S-mephenytoin 4′-hydroxylation
10. Involvement of CYP1A2 in mexiletine metabolism