A chimeric anti-TNFα monoclonal antibody (cA2) in vivo removes TNFα-producing cells in Crohn's disease

Human Antibodies

Volumn 10, Issue 2, 2001, Pages 91-94

  Urra, J M ^a   Arteta, M ^b   Gomez Caturla A ^b   Garcia Durn F ^b  

^a Cáceres   (Spain)

^b HOSPITAL SANTA BÁRBARA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; HYBRID PROTEIN;

ADULT; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CASE REPORT; CELL KILLING; CHIMERA; COLON BIOPSY; COLON CROHN DISEASE; COMPLEMENT DEPENDENT CYTOTOXICITY; GASTROINTESTINAL MUCOSA; HUMAN; MALE; MEDIATOR RELEASE; MEMBRANE BINDING; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; BIOSYNTHESIS; CASE CONTROL STUDY; CROHN DISEASE; FLOW CYTOMETRY; IMMUNOLOGY; PATHOLOGY;

ADULT; ANTIBODIES, MONOCLONAL; CASE-CONTROL STUDIES; CROHN DISEASE; FLOW CYTOMETRY; HUMANS; MALE; RECOMBINANT FUSION PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034740573     PISSN: 10932607     EISSN: None     Source Type: Journal    
DOI: 10.3233/hab-2001-10206     Document Type: Article

References (25)

1. Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis
2. Monoclonal anti-TNFα antibody as a probe of pathogenesis and therapy of rheumatoid disease
3. Role of cytokines in rheumatoid arthritis
4. Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification
5. Tumor necrosis factor α, Interleukin-1β, and Interleukin-6 expression in inflammatory bowel disease
6. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
7. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor-α for Crohn's disease
8. Increased Interleukin-2 messenger RNA in the intestinal mucosa lesion of Crohn's disease but not ulcerative colitis
9. Altered TH1/TH2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
10. The role of TNF-α in T-cell mediated inflammation depend on the Th1/Th2 balance
11. Early interleukin-12 production by macrophages in response to mycobacterial infection depends on interferon-γ and tumor necrosis factor-α
12. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex phisiology of TNF
13. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody
14. Chimeric anti-TNF-α monoclonal antibody cA2 binds recombinant transmembrane TNF-α and activates immune effector functions
15. Tumor Necrosis Factor-α antibody (Infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
16. TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53
17. hi CD4+ T cells
18. Chronic exposure to tumor necrosis factor (TNF) in vivo impairs the activation of T cells through the T cell receptor/CD3 complex: Reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis
19. Control of cachectin (tumor necrosis factor) synthesis: Mechanism of endotoxin resistance
20. Sulfasalazine inhibits the binding of TNF alpha to its receptor
21. Neutralization by the antibody cA2 reveals differential regulation on adhesion expression on TNF-activated endothelial cells
22. Local administration of anti-sense phosphorothioate oligonucleotides to the p65 subunit of NK-κB abrogates stablished experimental colitis in mice
23. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice
24. -/- mice upon transfer of CD4+ CD45RBhi T cells
25. Tumor necrosis factor antibody treatment in Crohn's disease