Involvement of the NH2 terminal domain of catecholamine transporters in the Na+ and Cl-dependence of a [3H]-dopamine uptake

British Journal of Pharmacology

Volumn 133, Issue 3, 2001, Pages 387-394

  Syringas, Maria ^a   Janin, François ^a   Giros, Bruno ^b   Costentin, Jean ^a   Bonnet, Jean Jacques ^a  

^a IFRMP 23   (France)

^b INSERM   (France)

Author keywords

Chimeric transporters; COS 7 transfected cells; Dopamine transport; Human dopamine transporter; Human noradrenaline transporter; Ions

Indexed keywords

CARRIER PROTEIN; CATECHOLAMINE; CHLORIDE ION; DOPAMINE; DOPAMINE TRANSPORTER; SODIUM ION; SUCROSE; CHLORIDE; COTRANSPORTER; HYBRID PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; NORADRENALIN TRANSPORTER; SLC6A2 PROTEIN, HUMAN; SODIUM; SODIUM CHLORIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN COS1; CHIMERA; DOPAMINE UPTAKE; NONHUMAN; PRIORITY JOURNAL; TRANSPORT KINETICS; ANIMAL; CELL LINE; CERCOPITHECUS; CHEMISTRY; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; KINETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL LINE; CERCOPITHECUS AETHIOPS; CHLORIDES; COS CELLS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; KINETICS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SODIUM; SODIUM CHLORIDE; SUCROSE; SYMPORTERS; TRANSFECTION;

EID: 0034740234     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704097     Document Type: Article

References (26)

1. + dependence of the neuronal transport of dopamine
2. Kinetic analysis of the chloride dependence of the neuronal uptake of dopamine and effect of anions on the ability of substrates to compete with the binding of the dopamine uptake inhibitor GBR 12783
3. Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter
4. Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium
5. Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants
6. - in transport
7. Molecular characterisation of the dopamine transporter
8. Cloning and functional characterization of a cocaine-sensitive dopamine transporter
9. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter
10. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
11. Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interaction using chimeric dopamine-norepinephrine transporters
12. Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence
13. Ion coupling stoichiometry for the norepinephrine transporter in membrane vesicles from stably transfected cells
14. Effects of monovalent ions on the transport of noradrenaline across the plasma membrane of neuronal cells (PC-12 cells)
15. 3H] dopamine into synaptosomes from rat striatum
16. Profound neuronal plasticity in response to inactivation of the dopamine transporter
17. + of the neuronal uptake of noradrenaline
18. Cloning and expression of a cocaine-sensitive rat dopamine transporter
19. Cellular and molecular aspects of monoamine neurotransmitter transporters
20. Synaptosomal transport: A chloride dependence for choline, gaba, glycine and several other compounds
21. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter
22. - of cocaine sensitive carrier-mediated efflux of amines from cells transfected with the cloned human catecholamine transporters
23. Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-pyridinium
24. Ion dependence of neurotransmitter uptake: Inhibitory effects of ion substitutes
25. --dependence of dopamine transport
26. Stoichiometry of transport systems