Preparation of1-(3-C-(propa-1,2-dienyl)d-ribo-pentofuranosyl)uracil, an allenic nucleoside

Nucleosides, Nucleotides and Nucleic Acids

Volumn 20, Issue 10-11, 2001, Pages 1775-1781

  Dauvergne, Jérôme ^a   Burger, Alain ^a   Biellmann, Jean François ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2,5 DI O (TERT BUTYLDIMETHYLSILYL) 3 C (PROPA 1,2 DIENYL) BETA DEXTRO RIBOPENTOFURANOSYL]URACIL; 1 [2,5 DI O (TERT BUTYLDIMETHYLSILYL) 3 C [(DIISOPROPYLAMINO)PROP 1 YNYL] BETA DEXTRO RIBOPENTOFURANOSYL]URACIL; 1 [3 C (PROPA 1,2 DIENYL) BETA DEXTRO RIBOPENTOFURANOSYL]URACIL; 1 [3 C [(DIISOPROPYLAMINO)PROP 1 YNYL] BETA DEXTRO RIBOPENTOFURANOSYL]URACIL; ALLENE DERIVATIVE; DIOXANE DERIVATIVE; MANNICH BASE; NUCLEOSIDE DERIVATIVE; SILANE DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG; URACIL DERIVATIVE; 1 (3 C (PROPA 1,2 DIENYL)PENTOFURANOSYL)URACIL; 1-(3-C-(PROPA-1,2-DIENYL)PENTOFURANOSYL)URACIL; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; URACIL; URIDINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG SCREENING; DRUG SYNTHESIS; ALLELE; ANIMAL; CELL CULTURE; CHEMICAL MODEL; IC 50; MOUSE; ULTRAVIOLET RADIATION;

ALLELES; ANIMAL; ANTINEOPLASTIC AGENTS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS; URACIL; URIDINE;

EID: 0034740179     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-100107189     Document Type: Article

References (10)

1. Nucleosides and nucleotides. 152. 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil as a broad spectrum antitumor nucleoside
2. Nucleosides and nucleotides. 158. 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil, and their nucleobase analogues as new potential multifunctional antitumor nucleosides with a broad spectrum of activity
3. Evaluation of the antitumoral properties of 1-(3′-C-ethynyl-β-D-ribofuranosyl)uracil (PJ272), a recent ribo-nucleoside analogue
4. Nucleosides and nucleotides. 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and-uracil
5. A convenient route to 2′-allenyl nucleosides
6. Observation on the synthesis of allenes by homologation of alk-1-ynes
7. Total synthesis of (±)-cis- and ±)-trans-trikentrin A: Diels-Alder reactions of heteroaromatic azadienes
8. Rapid and efficient stereocontrolled synthesis of C-3′-ethynyl ribo and xylonucleosides by organocerium additions to 3′-ketonucleosides
9. Diastereofacial selective addition of ethynylcerium reagent and Barton-Mccombie reaction as the key steps for the synthesis of C-3′-ethynylribonucleosides and of C-3′-ethynyl-2′-deoxyribonucleosides