Nucleosides and nucleotides, 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3- C-ethynyl-β-d-ribo-pentofuranosyl)cytosine and -uracil

Journal of Medicinal Chemistry

Volumn 41, Issue 15, 1998, Pages 2892-2902

  Hattori, Hideshi ^a   Nozawa, Eisuke ^a   Iino, Tomoharu ^a   Yoshimura, Yuichi ^a   Shuto, Satoshi ^a   Shimamoto, Yuji ^b   Nomura, Makoto ^a,b   Fukushima, Masakazu ^b   Tanaka, Motohiro ^c   Sasaki, Takuma ^c   Matsuda, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 ETHYNYL BETA DEXTRO RIBO PENTOFURANOSYL)URACIL; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; GROWTH INHIBITION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TUMOR CELL CULTURE; TUMOR GROWTH;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CARBOHYDRATE SEQUENCE; CELL DIVISION; CYTOSINE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KB CELLS; LEUKEMIA L1210; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RIBONUCLEOSIDES; SARCOMA 180; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL; URIDINE KINASE;

EID: 15644379995     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9801814     Document Type: Article

References (24)

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