Calcium-level responsive controlled drug delivery from implant dosage forms to treat osteoporosis in an animal model

Advanced Drug Delivery Reviews

Volumn 42, Issue 3, 2000, Pages 249-258

  Otsuka, Makoto ^a   Matsuda, Yoshihisa ^a   Baig, Arif A ^a   Chhettry, Anil ^a   Higuchi, William I ^b  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Apatitic bone cement; Bone mineral; Osteoporosis rats estradiol release; Plasma calcium level responsive drug release

Indexed keywords

BONE CEMENT; CALCIUM; COMPUTER SIMULATION; DRUG DOSAGE; DRUG PRODUCTS; PHYSIOLOGICAL MODELS;

APATITIC BONE CEMENT; BONE MINERAL; OSTEOPOROSIS;

CONTROLLED DRUG DELIVERY;

APATITE; CALCIUM; CALCIUM PHOSPHATE; ESTRADIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; BONE DENSITY; BONE MINERAL; BONE STRENGTH; CALCIUM BLOOD LEVEL; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG EFFECT; IMPLANTATION; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; REVIEW;

EID: 0034739299     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00065-X     Document Type: Article

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