Progestin receptors mediate progesterone suppression of epileptiform activity in tetanized hippocampal slices in vitro

Neuroscience

Volumn 101, Issue 4, 2000, Pages 895-906

  Edwards, H E ^a   Epps, T ^a   Carlen, P L ^a   MacLusky, N J ^a,b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c New York Presbyterian Hospital Columbia University Medical Center   (United States)

Author keywords

Allopregnanolone; Hippocampal slices; Progesterone; RU486; RU5020

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; CHOLESTEROL; ESTRADIOL; MIFEPRISTONE; PROGESTERONE; PROGESTERONE RECEPTOR; PROMEGESTONE;

AFTERDISCHARGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED RESPONSE; FEMALE; HIPPOCAMPUS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; SEIZURE; TETANY;

ANIMALS; DRUG COMBINATIONS; ELECTRIC STIMULATION; EPILEPSY; FEMALE; HIPPOCAMPUS; HORMONE ANTAGONISTS; MIFEPRISTONE; PREGNANOLONE; PROGESTERONE; PROGESTERONE CONGENERS; PROMEGESTONE; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, PROGESTERONE;

EID: 0034736257     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00439-5     Document Type: Article

References (53)

1. Development of a new pharmacological seizures model: effects of anticonvulsants on cortical- and amygdala-kindled seizures in the rat
2. Unit analysis of the hippocampal population spike
3. Regenerative, all-or-none electrographic seizures in the rat hippocampal slice in Mg-free and physiological medium
4. Progesterone-independent activation of rat brain progestin receptors by reproductive stimuli
5. Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle
6. Comparison of age- and sex-related changes in cell nuclear estrogen-binding capacity and progestin receptor induction in the rat brain
7. Cooperative interactions in the induction of long-term potentiation and depression of synaptic excitation between hippocampal CA3-CA1 cell pairs in vitro
8. Steroid hormones affect afterdischarge thresholds and kindling rates in the limbic system in adult female rats
9. Interictal EEG spikes correlate with decreased, rather than increased, epileptogenicity in amygdaloid kindled rats
10. Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures
11. Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3 alpha, 5 alpha-THP
12. Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus
13. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action
14. Relationships between triggered seizures, spontaneous seizures, and interictal spiking in the kindling model of epilepsy
15. Electroencephalographic spiking activity, drug levels, and seizure occurrence in epileptic patients
16. Plasma progesterone concentrations during pregnancy and lactation in the rat
17. The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABA(A) receptor
18. Intermittent progesterone therapy and frequency of complex partial seizures in women with menstrual disorders
19. The relationship between interictal and ictal paroxysms in an in vitro model of focal hippocampal epilepsy
20. An analysis of the actions of progabide, a specific GABA receptor agonist, on kindling and kindled seizures
21. Brain area specific differences in the effects of neuroactive steroids on the GABA(A) receptor complexes following acute treatment with anaesthetically active steroids
22. Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice
23. Neuroactive steroids protect against pilocarpine-induced and kainic acid-induced limbic seizures and status epilepticus in mice
24. Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition
25. Induction of lordosis behavior in female rats by intravenous administration of progestins
26. Interaction between 17β-oestradiol and 3α-hydroxy-5α-pregnane-20-one in the control of neuronal excitability in slices from the CA1 hippocampus in vitro of guinea-pigs and rats
27. Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin
28. The role of estrogens in catamenial exacerbation of epilepsy
29. Progesterone receptors in rat brain: distribution and properties of cytoplasmic progestin binding sites
30. Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites
31. Treatment of seizures with medroxyprogesterone acetate: preliminary report
32. Evaluation of the anticonvulsant profile of progesterone in male amygdala-kindled rats
33. 3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus
34. 2+ uptake by rat brain region synaptosomes following in vivo adminstration of ovarian steroids
35. An alternative ligand-independent pathway for activation of steroid receptors
36. A discontinuous schedule of estradiol treatment is sufficient to activate progesterone-facilitated feminine sexual behavior and to increase cytosol receptors for progestins in the hypothalamus of the rat
37. Progestin receptor levels in rat hypothalamic and limbic nuclei
38. Modulation of GABA(A) receptor mediated IPSCs by neuroactive steroids in rat hypothalmo-hypophyseal coculture model
39. Generation and propagation of epileptiform discharges in a combined entorhinal cortex/hippocampal slice
40. Long-duration self sustained epileptiform activity in the hippocampal-parahippocampal slice: a model of status epilepticus
41. Sex differences in rat brain oestrogen and progestin receptors
42. Progesterone 5α-reductase in mouse brain
43. Kindling: basic mechanisms and clinical validity
44. Regulation of high-affinity GABA(A) receptors in the dorsal hippocampus by estradiol and progesterone
45. Anti-seizure and anti-epileptogenic effects of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling
46. +-induced GABA and glutamate release from identified nerve terminals in rat hippocampus: a semiquantitative immunocytochemical study
47. A specific membrane binding protein for progesterone in rat brain: sex differences and induction by estrogen
48. The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor
49. Specific subunit mRNAs of the GABA(A) receptor are regulated by progesterone in subfields of the hippocampus
50. Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons
51. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat
52. Hormonal effects on the brain
53. Steroids conjugated to bovine serum albumen as tools to demonstrate specific steroid neuronal membrane binding sites