Aspects of gene regulation during the UPR in human cells

Biochemical and Biophysical Research Communications

Volumn 278, Issue 3, 2000, Pages 530-536

  Benedetti, Cristina ^a   Fabbri, Marco ^a   Sitia, Roberto ^a   Cabibbo, Andrea ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Differential display; Endoplasmic reticulum; ER stress; Heat shock protein; Protein folding

Indexed keywords

GENE PRODUCT; HEAT SHOCK PROTEIN; PROTEIN UPR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE CONTROL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN SYNTHESIS; RNA FINGERPRINTING;

EID: 0034736109     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3838     Document Type: Article

References (31)

1. Intracellular aspects of the process of protein synthesis
2. Protein folding in the cell
3. A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells
4. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
5. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
6. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
7. Cloning of mammalian Ire1 reveals diversity in the ER stress responses
8. The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex
9. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
10. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
11. The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control
12. A regulatory link between ER-associated protein degradation and the unfolded-protein response
13. Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway
14. Tripartite management of unfolded proteins in the endoplasmic reticulum
15. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
16. Mammalian stress response: Induction of the glucose-regulated protein family
17. Changes in gene expression during the growth arrest of HepG2 hepatoma cells induced by reducing agents or TGFbeta1
18. A computer-driven approach to PCR-based differential screening, alternative to differential display
19. Nuclear factor κB: An oxidative stress-responsive transcription factor of eukaryotic cells
20. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor
21. Coordinated regulation of a set of genes by glucose and calcium ionophore in mammalian cells
22. 2(+)-ATPase
23. Selective stimulation of the synthesis of an 80,000-dalton protein by calcium ionophores
24. Membrane biogenesis during B cell differentiation: Most endoplasmic reticulum proteins are expressed coordinately
25. Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response
26. Identification of novel stress-induced genes downstream of CHOP
27. Structure and expression of a human gene coding for a 71 kD heat shock 'cognate' protein
28. Phylogenetic analysis of the stress-70 protein family
29. Perk is essential for translational regulation and cell survival during the unfolded protein response
30. Complex regulation of heat shock- and glucose-responsive genes in human cells