Correlated motions in native proteins from MS analysis of NH exchange: Evidence for a manifold of unfolding reactions in ovomucoid third domain

Journal of Molecular Biology

Volumn 300, Issue 1, 2000, Pages 221-232

  Arrington, Cammon B ^a   Robertson, Andrew D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Electrospray mass spectrometry; Ensembles; Hydrogen exchange; Ovomucoid third domain; Protein unfolding

Indexed keywords

AMIDE; OVOMUCOID;

ALGORITHM; ARTICLE; CONTROLLED STUDY; MASS SPECTROMETRY; MOTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; TURKEY (BIRD);

AVES; MELEAGRIS GALLOPAVO;

EID: 0034733386     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3859     Document Type: Article

References (49)

1. Ligand binding to heme proteins: Relevance of low-temperature data
2. Defining protein ensembles with native-state NH exchange: Kinetics of interconversion and cooperative units from combined NMR and MS analysis
3. Primary structure effects on peptide group hydrogen exchange
4. Protein folding intermediates: Native-state hydrogen exchange
5. The crystal and molecular structure of the third domain of silver pheasant ovomucoid (OMSVP3)
6. Conformational transitions of proteins in water and in aqueous mixtures
7. Funnels, pathways, and the energy landscape of protein folding: A synthesis
8. Molten globule unfolding monitored by hydrogen exchange in urea
9. Detection of rare partially folded molecules in equilibrium with the native conformation of RNase H
10. Hydrogen exchange properties of proteins in native and denatured states monitored by mass spectrometry and NMR
11. Conformational adaptability in enzymes
12. The atomic structure of protein-protein recognition sites
13. Thermodynamic fluctuations in protein molecules
14. From Levinthal to pathways to funnels
15. Denatured states of proteins
16. Conformational isomerism and the diversity of antibodies
17. Conformational substates in proteins
18. The energy landscapes and motions of proteins
19. Flexibility and function in HIV protease: Dynamics of the HIV-1 protease bound to the asymmetric inhibitor kynostatin 272 (KNI-272)
20. Evidence for an obligatory intermediate in the folding of interleukin-1β
21. Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors
22. Functional significance of flexibility in proteins
23. Protein conformational stabilities can be determined from hydrogen exchange rates
24. A discussion of the pH dependence of the hydrogen-deuterium exchange of proteins
25. Single channel currents in the nicotinic acetylcholine receptor: A direct demonstration of allosteric transitions
26. Protein dynamics and conformational transitions in allosteric proteins
27. Heterogeneity of the binding sites of bovine serum albumin
28. The internal dynamics of globular proteins
29. The dynamics of proteins
30. Protein dynamics from NMR
31. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
32. Protein structure and enzyme activity
33. Thermal denaturation of Escherichia coli thioredoxin studied by hydrogen/deuterium exchange and electrospray ionization mass spectrometry: Monitoring a two-state protein unfolding transition
34. Detection of transient protein folding populations by mass spectrometry
35. Rate of conformational transitions in biological macromolecules and their analogs
36. A statistical mechanical model for β-hairpin kinetics
37. The cooperativity of burst phase reactions explored
38. Hydrogen exchange in native and denatured states of hen egg-white lysozyme
39. NMR spectroscopy in structure-based drug design
40. 2H and temperature
41. 15N-labeled helical peptides measured by isotope-edited NMR
42. Conformational isomers of a class II MHC-peptide complex in solution
43. Distribution of helicity within the model peptide acetyl (AAAQAA)3amide
44. The concept of a random coil. Residual structure in peptides and denatured proteins
45. A model of protein conformational substates
46. Temperature and pH dependences of hydrogen exchange and global stability for ovomucoid third domain
47. A model of the changes in denatured state structure underlying m value effects in staphylococcal nuclease
48. Structure based prediction of protein folding intermediates
49. Direct evidence for a two-state protein unfolding transition from hydrogen-deuterium exchange, mass spectrometry, and NMR