The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1

DNA Research

Volumn 7, Issue 3, 2000, Pages 233-235

  Vincent, John B ^a   Skaug, Jennifer ^a   Scherer, Stephen W ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CELSR2 PROTEIN, HUMAN; CELSR2 PROTEIN, MOUSE; COMPLEMENTARY DNA; DROSOPHILA PROTEIN; EPIDERMAL GROWTH FACTOR; MESSENGER RNA; STAN PROTEIN, DROSOPHILA;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; BRAIN; CHEMISTRY; CHROMOSOME 1; CHROMOSOME MAP; DROSOPHILA; EXPRESSED SEQUENCE TAG; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LIBRARY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; NORTHERN BLOTTING; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, NORTHERN; BRAIN; CADHERINS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; DNA, COMPLEMENTARY; DROSOPHILA; DROSOPHILA PROTEINS; EPIDERMAL GROWTH FACTOR; EXPRESSED SEQUENCE TAGS; GENE LIBRARY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RATS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION;

EID: 0034733210     PISSN: 13402838     EISSN: None     Source Type: Journal    
DOI: 10.1093/dnares/7.3.233     Document Type: Article

References (7)

1. Apella, E., Weber, I. T., and Blasi, F. 1988, Structure and function of epidermal growth factor-like regions in proteins, FEBS Lett., 231, 1-4.
2. Rusch, V., Mendelsohn, J., and Dmitrovsky, E. 1996, The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors, Cytokine Growth Factor Rev., 7, 133-141.
3. Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N., and Nomura. N. 1996, Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain, DNA Res., 3, 321-329.
4. Usui, T., Shima, Y., Shimado, Y., Hirano, S., Burgess, R. W., Schwarz, T. L., Takeichi, M., and Uemara, T. 1999, Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of frizzled, Cell, 98, 585-595.
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6. Nakayama, M., Makajima, D., Nagase, T., Nomura, N., Seki, N., and Ohara, O. 1998, Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening, Genomics, 51, 27-34.
7. Wu, Q. and Maniatis, T. 2000, Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes, Proc Natl Acad Sci. USA, 97, 3124-3129.